{"id":1670,"date":"2023-06-25T17:29:32","date_gmt":"2023-06-25T17:29:32","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/betaxolol-hydrochloride\/"},"modified":"2023-06-25T19:49:57","modified_gmt":"2023-06-25T19:49:57","slug":"betaxolol-hydrochloride","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/betaxolol-hydrochloride\/","title":{"rendered":"Betaxolol hydrochloride"},"content":{"rendered":"

<\/p>\n

Betaxolol hydrochloride<\/h1>\n

CLINICAL USE<\/h3>\n

Hyperlipidaemia<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

200 mg, 3 times a day Modified release: 400 mg daily<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           :361.8<\/li>\n
  • %Protein binding                           :95<\/li>\n
  • %Excreted unchanged in urine     : 50<\/li>\n
  • Volume of distribution (L\/kg)       :0.24\u20130.35<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :1\u20132 (XL: 3.4)\/7.8\u201320
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n

    40\u201360 400 mg daily15\u201340 200 mg every 24\u201348 hours<15 Avoid<\/p>\n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Not dialysed. 200 mg every 72 hours<\/li>\n
  • HD                     :Not dialysed. 200 mg every 72 hours<\/li>\n
  • HDF\/high flux   :Unknown dialysability. 200 mg every 72 hours<\/li>\n
  • CAV\/VVHD      :Unknown dialysability. Dose as in GFR=15\u201340 mL\/min
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugsAntibacterials: increased risk of myopathy with daptomycin \u2013 try to avoid concomitant useAnticoagulants: enhances effect of coumarins and phenindione; dose of anticoagulant should be reduced by up to 50% and adjusted by monitoring INRAntidiabetics: may improve glucose tolerance and have an additive effect with insulin or sulphonylureasCiclosporin: may increase nephrotoxicity and reduce ciclosporin levelsLipid-regulating drugs: increased risk of myopathy in combination with statins and ezetimibe \u2013 avoid with ezetimibe; do not exceed 10 mg of simvastatin1<\/p>\n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Take dose with or after food Contraindicated in nephrotic syndrome There should be an interval of 2 hours between intake of ion exchange resin and bezafibrateModified-release preparation is not appropriate in renal impairment<\/li>\n","protected":false},"excerpt":{"rendered":"

    Betaxolol hydrochloride CLINICAL USE Hyperlipidaemia DOSE IN NORMAL RENAL FUNCTION<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1670","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1670","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1670"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1670\/revisions"}],"predecessor-version":[{"id":2890,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1670\/revisions\/2890"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1670"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1670"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1670"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}