{"id":1669,"date":"2023-06-25T17:29:32","date_gmt":"2023-06-25T17:29:32","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/betamethasone\/"},"modified":"2023-06-25T19:49:54","modified_gmt":"2023-06-25T19:49:54","slug":"betamethasone","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/betamethasone\/","title":{"rendered":"Betamethasone"},"content":{"rendered":"

<\/p>\n

Betamethasone<\/h1>\n

CLINICAL USE<\/h3>\n

Corticosteroid:<\/p>\n

  • Suppression of inflammatory and allergic disorders<\/li>\n
  • Congenital adrenal hyperplasia
    \n

    DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

    Oral: 0.5\u20135 mg dailyInjection: 4\u201320 mg repeated up to 4 times in 24 hours<\/p>\n

    PHARMACOKINETICS<\/h3>\n<\/li>\n
  • Molecular weight                           :392.5<\/li>\n
  • %Protein binding                           :65<\/li>\n
  • %Excreted unchanged in urine     : 5<\/li>\n
  • Volume of distribution (L\/kg)       :1.4<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :5.5\/\u2013
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           : Dose as in normal renal function
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Unknown dialysability. Dose as in normal renal function<\/li>\n
  • HD                     :Unknown dialysability. Dose as in normal renal function<\/li>\n
  • HDF\/high flux   :Unknown dialysability. Dose as in normal renal function<\/li>\n
  • CAV\/VVHD      :Unknown dialysability. Dose as in normal renal function
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Antibacterials: metabolism accelerated by rifampicin; metabolism possibly inhibited by erythromycin<\/li>\n
  • Anticoagulants: efficacy of coumarins may be altered<\/li>\n
  • Anti-epileptics: metabolism accelerated by carbamazepine, barbiturates, phenytoin and primidoneAntifungals: increased risk of hypokalaemia with amphotericin \u2013 avoid concomitant use; metabolism possibly inhibited by itraconazole and ketoconazoleA<\/li>\n
  • ntivirals: concentration possibly increased by ritonavir<\/li>\n
  • Ciclosporin: rare reports of convulsions in patients on ciclosporin and high-dose corticosteroids<\/li>\n
  • Cytotoxics: increased risk of haematological toxicity with methotrexate<\/li>\n
  • Diuretics: enhanced hypokalaemic effects of acetazolamide, loop diuretics and thiazide diuretics<\/li>\n
  • Vaccines: high-dose corticosteroids can impair immune response to vaccines; avoid concomitant use with live vaccines
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Orally, IV, IM, topically<\/p>\n

    Rate of Administration<\/h4>\n

    IV bolus: over half to one minute<\/p>\n

    Comments<\/h4>\n

    Can be added to glucose 5% or sodium chloride 0.9%<\/p>\n

    OTHER INFORMATION<\/h4>\n<\/li>\n
  • 750 micrograms betamethasone \u2261 5 mg prednisolone<\/li>\n
  • Even when applied topically, sufficient corticosteroid may be absorbed to give a systemic effec<\/li>\n
  • tEffects of betamethasone on sodium and water retention are less than those of prednisolone and approximately equal to those of dexamethasone<\/li>\n","protected":false},"excerpt":{"rendered":"

    Betamethasone CLINICAL USE Corticosteroid: Suppression of inflammatory and allergic disorders<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1669","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1669","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1669"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1669\/revisions"}],"predecessor-version":[{"id":2889,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1669\/revisions\/2889"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1669"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1669"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1669"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}