{"id":1668,"date":"2023-06-25T17:29:32","date_gmt":"2023-06-25T17:29:32","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/betahistine-dihydrochloride\/"},"modified":"2023-06-25T19:47:34","modified_gmt":"2023-06-25T19:47:34","slug":"betahistine-dihydrochloride","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/betahistine-dihydrochloride\/","title":{"rendered":"Betahistine dihydrochloride"},"content":{"rendered":"

<\/p>\n

Betahistine dihydrochloride<\/h1>\n

CLINICAL USE<\/h3>\n

Treatment of vertigo, tinnitus and hearing loss associated with M\u00e9ni\u00e8re\u2019s syndrome<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

8\u201316 mg, 3 times a day<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           :209.1<\/li>\n
  • %Protein binding                           :0\u20135<\/li>\n
  • %Excreted unchanged in urine     : 85\u201390<\/li>\n
  • Volume of distribution (L\/kg)       :No data<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :3.4\/\u2013
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           : 8\u201316 mg, 2\u20133 times a day
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Likely dialysability. Dose as in GFR <10 mL\/min<\/li>\n
  • HD                     :Likely dialysability. Dose as in GFR <10 mL\/min<\/li>\n
  • HDF\/high flux   :Likely dialysability. Dose as in GFR <10 mL\/min<\/li>\n
  • CAV\/VVHD      :Likely dialysability. Dose as in GFR 10 to 20 mL\/min
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugsNone known<\/p>\n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n<\/li>\n
  • Betahistine is rapidly and completely absorbed after oral administration<\/li>\n
  • It is excreted almost exclusively in the urine as 2-pyridylacetic acid within 24 hours of administration<\/li>\n","protected":false},"excerpt":{"rendered":"

    Betahistine dihydrochloride CLINICAL USE Treatment of vertigo, tinnitus and hearing<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1668","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1668","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1668"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1668\/revisions"}],"predecessor-version":[{"id":2870,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1668\/revisions\/2870"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1668"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1668"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1668"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}