{"id":1666,"date":"2023-06-25T17:29:32","date_gmt":"2023-06-25T17:29:32","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/benzbromarone\/"},"modified":"2023-06-25T19:50:49","modified_gmt":"2023-06-25T19:50:49","slug":"benzbromarone","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/benzbromarone\/","title":{"rendered":"Benzbromarone"},"content":{"rendered":"

<\/p>\n

Benzbromarone<\/h1>\n

CLINICAL USE<\/h3>\n

Treatment of hyperuricaemia, chronic gout and tophaceous gout<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

50\u2013200 mg daily(Usual dose 50\u2013100 mg daily)<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           :424.1<\/li>\n
  • %Protein binding                           :>99<\/li>\n
  • %Excreted unchanged in urine     : 6\u201318 (as metabolites)<\/li>\n
  • Volume of distribution (L\/kg)       :19 litres<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :2\u20134
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n

    40\u201360 50\u2013200 mg daily120\u201340 50\u2013100 mg daily1<20 Avoid. Ineffective<\/p>\n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Avoid. Ineffective<\/li>\n
  • HD                     :Avoid. Ineffective<\/li>\n
  • HDF\/high flux   :Avoid. Ineffective<\/li>\n
  • CAV\/VVHD      :Use with caution. Dose as in GFR=20\u201340 mL\/min
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugsA<\/li>\n

  • spirin and salicylates: antagonise uricosuric effects of benzbromarone<\/li>\n
  • Anticoagulants: may enhance effect of warfarinPyrazinamide: antagonise uricosuric effects of benzbromarone<\/li>\n
  • Hepatotoxic agents: enhanced hepatotoxicity
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Monitor LFTs while on benzbromarone as can cause fulminant liver failure<\/li>\n

  • As with other uricosurics, treatment with benzbromarone should not be started during an acute attack of gout<\/li>\n
  • Maintain an adequate fluid intake to reduce the risk of uric acid renal calculi<\/li>\n
  • Biological effect of 100 mg benzbromarone is equivalent to 1.5 g probenecid or greater than 300 mg of allopurinol.<\/li>\n
  • Benzbromarone is considered unsafe in patients with acute porphyria<\/li>\n","protected":false},"excerpt":{"rendered":"

    Benzbromarone CLINICAL USE Treatment of hyperuricaemia, chronic gout and tophaceous<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1666","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1666","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1666"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1666\/revisions"}],"predecessor-version":[{"id":2900,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1666\/revisions\/2900"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1666"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1666"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1666"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}