{"id":1665,"date":"2023-06-25T17:29:32","date_gmt":"2023-06-25T17:29:32","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/benzatropine-mesilate\/"},"modified":"2023-06-25T19:50:46","modified_gmt":"2023-06-25T19:50:46","slug":"benzatropine-mesilate","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/benzatropine-mesilate\/","title":{"rendered":"Benzatropine mesilate"},"content":{"rendered":"

<\/p>\n

Benzatropine mesilate<\/h1>\n

CLINICAL USE<\/h3>\n
  • Parkinson\u2019s disease<\/li>\n
  • Drug-induced extrapyramidal side effects
    \n

    DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

    IV\/IM (emergency use): 1\u20132 mg<\/p>\n

    PHARMACOKINETICS<\/h3>\n<\/li>\n
  • Molecular weight                           :403.5<\/li>\n
  • %Protein binding                           :95<\/li>\n
  • %Excreted unchanged in urine     : Majority (as unchanged drug and metabolites)<\/li>\n
  • Volume of distribution (L\/kg)       :<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Start with low doses and adjust according to response<\/li>\n
  • 10 to 20     : Start with low doses and adjust according to response<\/li>\n
  • <10           : Start with low doses and adjust according to response
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Unknown dialysability. Dose as in GFR <10 mL\/min<\/li>\n
  • HD                     :Unknown dialysability. Dose as in GFR <10 mL\/min<\/li>\n
  • HDF\/high flux   :Unknown dialysability. Dose as in GFR <10 mL\/min<\/li>\n
  • CAV\/VVHD      :Unknown dialysability. Dose as in GFR 10 to 20 mL\/min
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugsPhenothiazines and tricyclic anti- depressants: may cause paralytic ileus which can be fatal<\/p>\n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    IV, IM<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n<\/li>\n
  • Benzatropine pharmacokinetics are not well studied, but the drug apparently is hepatically metabolised to conjugates and may undergo entero-hepatic recycling<\/li>\n
  • Benzatropine has a cumulative effect and a prolonged duration of action; therefore, treatment should commence with the lowest possible dosage and be titrated according to response<\/li>\n","protected":false},"excerpt":{"rendered":"

    Benzatropine mesilate CLINICAL USE Parkinson\u2019s disease Drug-induced extrapyramidal side effects<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1665","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1665","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1665"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1665\/revisions"}],"predecessor-version":[{"id":2899,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1665\/revisions\/2899"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1665"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1665"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1665"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}