{"id":1664,"date":"2023-06-25T17:29:32","date_gmt":"2023-06-25T17:29:32","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/bendroflumethiazide\/"},"modified":"2023-06-25T19:50:43","modified_gmt":"2023-06-25T19:50:43","slug":"bendroflumethiazide","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/bendroflumethiazide\/","title":{"rendered":"Bendroflumethiazide"},"content":{"rendered":"

<\/p>\n

Bendroflumethiazide<\/h1>\n

CLINICAL USE<\/h3>\n

Thiazide diuretic:<\/p>\n

  • Hypertension<\/li>\n
  • Oedema
    \n

    DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

    Oedema: 5\u201310 mg in the morning or alternate days<\/li>\n

  • Maintenance: 5\u201310 mg, 1\u20133 times weekly<\/li>\n
  • Hypertension: 2. 5 mg daily
    \n

    PHARMACOKINETICS<\/h3>\n<\/li>\n
  • Molecular weight                           :421.4<\/li>\n
  • %Protein binding                           :94<\/li>\n
  • %Excreted unchanged in urine     : 30<\/li>\n
  • Volume of distribution (L\/kg)       :1.2\u20131.5<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :3\u20139\/\u2013
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           : Unlikely to work
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Unlikely to be dialysed. Unlikely to work.<\/li>\n
  • HD                     :Not dialysed. Unlikely to work<\/li>\n
  • HDF\/high flux   :Unknown dialysability. Unlikely to work<\/li>\n
  • CAV\/VVHD      :Probably not dialysed. Unlikely to work
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Analgesics: increased risk of nephrotoxicity with NSAIDs; antagonism of diuretic effect<\/li>\n
  • Anti-arrhythmics: hypokalaemia leads to increased cardiac toxicity; effects of lidocaine and mexiletine antagonised<\/li>\n
  • Antibacterials: avoid administration with lymecycline<\/li>\n
  • Antidepressants: increased risk of hypokalaemia with reboxetine; enhanced hypotensive effect with MAOIs; increased risk of postural hypotension with tricyclics<\/li>\n
  • Anti-epileptics: increased risk of hyponatraemia with carbamazepine<\/li>\n
  • Antifungals: increased risk of hypokalaemia with amphotericinAntihypertensives: enhanced hypotensive effect; increased risk of first dose hypotension with post-synaptic alpha-blockers like prazosin; hypokalaemia increases risk of ventricular arrhythmias with sotalol<\/li>\n
  • Antipsychotics: hypokalaemia increases risk of ventricular arrhythmias with amisulpride or sertindole; enhanced hypotensive effect with phenothiazines; hypokalaemia increases risk of ventricular arrhythmias with pimozide \u2013 avoid concomitant use<\/li>\n
  • Atomoxetine: hypokalaemia increases risk of ventricular arrhythmias<\/li>\n
  • Cardiac glycosides: increased toxicity if hypokalaemia occurs<\/li>\n
  • Ciclosporin: increased risk of nephrotoxicity and hypomagnesaemia<\/li>\n
  • Lithium excretion reduced, increased toxicity
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Monitor for hypokalaemia Thiazide diuretics are unlikely to be of use once GFR<30 mL\/min<\/li>\n","protected":false},"excerpt":{"rendered":"

    Bendroflumethiazide CLINICAL USE Thiazide diuretic: Hypertension Oedema DOSE IN NORMAL<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1664","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1664","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1664"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1664\/revisions"}],"predecessor-version":[{"id":2898,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1664\/revisions\/2898"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1664"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1664"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1664"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}