{"id":1661,"date":"2023-06-25T17:29:32","date_gmt":"2023-06-25T17:29:32","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/balsalazide-sodium\/"},"modified":"2023-06-25T19:48:46","modified_gmt":"2023-06-25T19:48:46","slug":"balsalazide-sodium","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/balsalazide-sodium\/","title":{"rendered":"Balsalazide sodium"},"content":{"rendered":"

<\/p>\n

Balsalazide sodium<\/h1>\n

CLINICAL USE<\/h3>\n

Treatment, and maintenance of remission, in mild to moderate ulcerative colitis<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

Acute treatment: 2.25 g, 3 times a dayMaintenance: 1.5 g twice daily, maximum 6 g\/day<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           :437.3<\/li>\n
  • %Protein binding                           :40 (similar to mesalazine), (NASA \u2013 80%)<\/li>\n
  • %Excreted unchanged in urine     : 25 (as metabolites)<\/li>\n
  • Volume of distribution (L\/kg)       :No data<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :No data (T\u00bd NASA = 6\u20139)
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Use with caution and only if necessary<\/li>\n
  • <10           : Start with low doses and monitor closely
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Unlikely to be dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • HD                     :Unlikely to be dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • HDF\/high flux   :Unlikely to be dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • CAV\/VVHD      :Unknown dialysability. Dose as in GFR 10 to 20 mL\/min
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugsNone known<\/p>\n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n<\/li>\n
  • Balsalazide is a prodrug of mesalazine (5-amino-salicylic acid)<\/li>\n
  • Mesalazine is best avoided in patients with established renal impairment, but if necessary should be used with caution and the patient carefully monitored<\/li>\n
  • Serious blood dyscrasias have been reported with mesalazine \u2013 monitor full blood count closely<\/li>\n","protected":false},"excerpt":{"rendered":"

    Balsalazide sodium CLINICAL USE Treatment, and maintenance of remission, in<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1661","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1661","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1661"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1661\/revisions"}],"predecessor-version":[{"id":2880,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1661\/revisions\/2880"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1661"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1661"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1661"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}