{"id":1660,"date":"2023-06-25T17:29:32","date_gmt":"2023-06-25T17:29:32","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/baclofen\/"},"modified":"2023-06-25T19:50:40","modified_gmt":"2023-06-25T19:50:40","slug":"baclofen","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/baclofen\/","title":{"rendered":"Baclofen"},"content":{"rendered":"

<\/p>\n

Baclofen<\/h1>\n

CLINICAL USE<\/h3>\n

Chronic severe spasticity of voluntary muscles<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

5 mg, 3 times a day; increase dose gradually up to 100 mg\/day<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           :213.7<\/li>\n
  • %Protein binding                           :30<\/li>\n
  • %Excreted unchanged in urine     : 70<\/li>\n
  • Volume of distribution (L\/kg)       :0.7<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :3\u20134\/\u2013
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : 5 mg, 3 times a day and titrate according to response<\/li>\n
  • 10 to 20     : 5 mg, twice a day and titrate according to response<\/li>\n
  • <10           : 5 mg, once a day and titrate according to response
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Unknown dialysability. Dose as in GFR <10 mL\/min<\/li>\n
  • HD                     :Dialysed.1 Dose as in GFR<\/li>\n
  • <10           : mL\/min<\/li>\n
  • HDF\/high flux   :Dialysed.1 Dose as in GFR<\/li>\n
  • <10           : mL\/min<\/li>\n
  • CAV\/VVHD      :Unknown dialysability. Dose as in GFR 10 to 20 mL\/min
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Anti-arrhythmics: enhanced muscle relaxant effect with procainamide<\/li>\n
  • Antidepressants: enhanced muscle relaxant effect with tricyclics<\/li>\n
  • Antihypertensives: enhanced hypotensive effect
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral, intrathecal injection<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n<\/li>\n
  • Take with or after food<\/li>\n
  • Baclofen can be given intrathecally (at doses greatly reduced compared with oral dose), by bolus injection, or continuous infusion. Individual titration of dosage is essential due to variability in response. Test doses must be given. Maintenance dose: 10\u20132000 micrograms\/day
    \n

    OTHER INFORMATION<\/h4>\n

    W<\/li>\n

  • ithdraw treatment gradually over 1\u20132 weeks to avoid anxiety and confusional state, etc<\/li>\n
  • Drowsiness and nausea frequent at the start of therapy<\/li>\n
  • Use with caution as a case report of encephalopathy has been reported in a haemodialysis patient.<\/li>\n","protected":false},"excerpt":{"rendered":"

    Baclofen CLINICAL USE Chronic severe spasticity of voluntary muscles DOSE<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1660","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1660","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1660"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1660\/revisions"}],"predecessor-version":[{"id":2897,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1660\/revisions\/2897"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1660"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1660"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1660"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}