{"id":1659,"date":"2023-06-25T17:29:32","date_gmt":"2023-06-25T17:29:32","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/aztreonam\/"},"modified":"2023-06-25T19:47:27","modified_gmt":"2023-06-25T19:47:27","slug":"aztreonam","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/aztreonam\/","title":{"rendered":"Aztreonam"},"content":{"rendered":"

<\/p>\n

Aztreonam<\/h1>\n

CLINICAL USE<\/h3>\n

Antibacterial agent<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n
  • 1 g every 8 hours or 2 g every 12 hours<\/li>\n
  • Severe infections: 2 g every 6\u20138 hours<\/li>\n
  • UTI: 0.5\u20131 g every 8\u201312 hours
    \n

    PHARMACOKINETICS<\/h3>\n<\/li>\n
  • Molecular weight                           :435.4<\/li>\n
  • %Protein binding                           :60<\/li>\n
  • %Excreted unchanged in urine     : 60\u201370<\/li>\n
  • Volume of distribution (L\/kg)       :0.5\u20131<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :1.7\/6\u20138
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n

    30\u201350 Dose as in normal renal function10\u201330 1\u20132 g loading dose, then maintenance of 50% of appropriate normal dose<\/li>\n

  • <10           : 1\u20132 g loading dose, then maintenance of 25% of appropriate normal dose
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Not dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • HD                     :Dialysed. Dose as in GFR<\/li>\n
  • <10           : mL\/min<\/li>\n
  • HDF\/high flux   :Dialysed. Dose as in GFR<\/li>\n
  • <10           : mL\/min<\/li>\n
  • CAV\/VVHD      :Dialysed. Loading dose of 2 g then 1\u20132 g every 12 hours1,2 CVVhd\/HDFDialysed. 2 g every 12 hours2
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugsPossibly enhanced anticoagulant effect of coumarins<\/p>\n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    3 mL of water for injection per 1 g vial<\/p>\n

    Route<\/h4>\n

    IM, IV bolus,<\/p>\n

    IV infusion<\/h4>\n

    Rate of Administration<\/h4>\n

    IM injection: Give by deep injection into a large muscle massIV: Slowly inject directly into the vein over a period of 3\u20135 minutes<\/p>\n

    IV infusion<\/h4>\n

    : Give over 20\u201360 minutes<\/p>\n

    Comments<\/h4>\n

    Suitable infusion solutions: glucose 5%, sodium chloride 0.9%, compound sodium lactateDilute to a concentration of not less than 20 mg\/mLOnce reconstituted aztreonam can be stored in a refrigerator for 24 hoursIV route recommended for single doses >1 g<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Manufacturers recommend that patients with renal impairment be given the usual initial dose followed by a maintenance dose adjusted according to creatinine clearance.<\/li>\n

  • The normal dose interval should not be altered<\/li>\n","protected":false},"excerpt":{"rendered":"

    Aztreonam CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL FUNCTION<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1659","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1659","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1659"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1659\/revisions"}],"predecessor-version":[{"id":2871,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1659\/revisions\/2871"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1659"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1659"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1659"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}