{"id":1658,"date":"2023-06-25T17:29:32","date_gmt":"2023-06-25T17:29:32","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/azithromycin\/"},"modified":"2023-06-25T19:50:37","modified_gmt":"2023-06-25T19:50:37","slug":"azithromycin","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/azithromycin\/","title":{"rendered":"Azithromycin"},"content":{"rendered":"

<\/p>\n

Azithromycin<\/h1>\n

CLINICAL USE<\/h3>\n

Antibacterial agent<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n
  • Genital chlamydial infections: 1 g as single dose<\/li>\n
  • All other indications: 500 mg daily for 3 days<\/li>\n
  • Typhoid (unlicensed): 500 mg daily for 7 days
    \n

    PHARMACOKINETICS<\/h3>\n<\/li>\n
  • Molecular weight                           :785<\/li>\n
  • %Protein binding                           :12\u201352<\/li>\n
  • %Excreted unchanged in urine     : 6\u201312<\/li>\n
  • Volume of distribution (L\/kg)       :31.1<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :48\u201396\/\u2013
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           : Dose as in normal renal function
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Not dialysed. Dose as in normal renal function<\/li>\n
  • HD                     :Unknown dialysability. Dose as in normal renal function<\/li>\n
  • HDF\/high flux   :Unknown dialysability. Dose as in normal renal function<\/li>\n
  • CAV\/VVHD      :Unknown dialysability. Dose as in normal renal function
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Antibacterials: possibly increased rifabutin concentration (increased risk of uveitis) \u2013 reduce dose of rifabutin)<\/li>\n
  • Anticoagulants: effect of coumarins may be enhanced<\/li>\n
  • Antidepressants: the manufacturer of reboxetine advises to avoid concomitant use<\/li>\n
  • Antihistamines: may inhibit the metabolism of mizolastine (risk of hazardous arrhythmias) \u2013 avoid concomitant use<\/li>\n
  • Antimalarials: avoid concomitant use with artemether\/lumefantrine<\/li>\n
  • Antipsychotics: possibly increased quetiapine concentration \u2013 reduce quetiapine dose; possibly increased risk of ventricular arrhythmias with sertindole \u2013 avoid concomitant use<\/li>\n
  • Antivirals: concentration possibly increased by ritonavir<\/li>\n
  • Ciclosporin: may inhibit the metabolism of ciclosporin (increased plasma ciclosporin levels)<\/li>\n
  • Ergot alkaloids: increased risk of ergotism \u2013 avoid concomitant use<\/li>\n
  • Theophylline: possibly increased theophylline concentration
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    Powder for oral suspension to be reconstituted with water (200 mg\/5 mL strength)<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    Administer as a once daily dose 1 hour before food or 2 hours after food.<\/li>\n","protected":false},"excerpt":{"rendered":"

    Azithromycin CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL FUNCTION<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1658","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1658","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1658"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1658\/revisions"}],"predecessor-version":[{"id":2896,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1658\/revisions\/2896"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1658"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1658"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1658"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}