{"id":1656,"date":"2023-06-25T17:29:05","date_gmt":"2023-06-25T17:29:05","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/auranofin\/"},"modified":"2023-06-25T19:49:40","modified_gmt":"2023-06-25T19:49:40","slug":"auranofin","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/auranofin\/","title":{"rendered":"Auranofin"},"content":{"rendered":"

<\/p>\n

Auranofin<\/h1>\n

CLINICAL USE<\/h3>\n

Active progressive rheumatoid arthritis in adults when NSAIDs inadequate alone<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

6 mg daily (maximum 9 mg in 3 divided doses)<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           :678.5<\/li>\n
  • %Protein binding                           :60<\/li>\n
  • %Excreted unchanged in urine     : 9\u201317 (approx 60% of absorbed gold)<\/li>\n
  • Volume of distribution (L\/kg)       :No data<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :26 days\/ \u2013
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : 3\u20136 mg daily<\/li>\n
  • 10 to 20     : 3 mg daily<\/li>\n
  • <10           : Avoid
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Unknown dialysability. Dose as in GFR <10 mL\/min<\/li>\n
  • HD                     :Not dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • HDF\/high flux   :Unknown dialysability. Dose as in GFR <10 mL\/min<\/li>\n
  • CAV\/VVHD      :Not dialysed. Dose as in GFR=10\u201320 mL\/min
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugsNone known<\/p>\n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    Take with or after food Start initially with morning and evening dose; if well tolerated, can take dose once a day<\/p>\n

    OTHER INFORMATION<\/h4>\n<\/li>\n
  • Warn patients to tell the doctor immediately if any of the following develop: sore throat, mouth ulcers, bruising, fever, malaise, rash, diarrhoea or non-specific illness<\/li>\n
  • Blood tests should be carried out monthly, and treatment should be withdrawn if the platelets fall below 100 000\/mm3, or if signs and symptoms suggestive of thrombocytopenia appear<\/li>\n
  • Gold can produce nephrotic syndrome or less severe glomerular disease with proteinuria and haematuria, which are usually mild and transient. If persistent or clinically significant proteinuria develops, treatment with gold should be discontinued. Minor transient changes in renal function may also occur<\/li>\n
  • Urine tests should be carried out monthly to test for proteinuria and haematuria<\/li>\n","protected":false},"excerpt":{"rendered":"

    Auranofin CLINICAL USE Active progressive rheumatoid arthritis in adults when<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1656","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1656","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1656"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1656\/revisions"}],"predecessor-version":[{"id":2886,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1656\/revisions\/2886"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1656"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1656"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1656"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}