{"id":1651,"date":"2023-06-25T17:29:04","date_gmt":"2023-06-25T17:29:04","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/atazanavir\/"},"modified":"2023-06-25T19:59:32","modified_gmt":"2023-06-25T19:59:32","slug":"atazanavir","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/atazanavir\/","title":{"rendered":"Atazanavir"},"content":{"rendered":"

<\/p>\n

Atazanavir<\/h1>\n

CLINICAL USE<\/h3>\n

Protease inhibitor:<\/p>\n

  • HIV infection, in combination with otherantiretroviral drugs
    \n

    DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

    300 mg once daily with ritonavir 100 mg once
    \ndaily<\/p>\n

    PHARMACOKINETICS<\/h3>\n<\/li>\n
  • Molecular weight                           :
    \n802.9 (as sulphate)<\/li>\n
  • %Protein binding                           :
    \n86<\/li>\n
  • %Excreted unchanged in urine     :
    \n7<\/li>\n
  • Volume of distribution (L\/kg)       :
    \nNo data<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :
    \n7\/no data<\/p>\n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           :
    \nDose as in normal renal function<\/p>\n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :
    \nUnlikely to be dialysed. Dose as in
    \nnormal renal function<\/li>\n
  • HD                     :
    \nUnlikely to be dialysed. Dose as in
    \nnormal renal function<\/li>\n
  • HDF\/high flux   :
    \nUnlikely to be dialysed. Dose as in
    \nnormal renal function<\/li>\n
  • CAV\/VVHD      :
    \nUnknown dialysability. Dose as in
    \nnormal renal function<\/p>\n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Anti-arrhythmics: possibly increasedplasma levels of amiodarone and lidocaine<\/li>\n
  • Antibacterials: concentration of bothdrugs increased when given with
    \nclarithromycin; rifabutin concentration
    \nincreased \u2013 reduce dose of rifabutin;
    \nrifampicin reduces atazanavir
    \nconcentration \u2013 avoid concomitant use;
    \navoid concomitant use with telithromycin
    \nin severe renal and hepatic impairment<\/li>\n
  • Antidepressants: concentration reduced bySt John\u2019s wort \u2013 avoid concomitant use<\/li>\n
  • Antimalarials: avoid concomitantadministration with artemether\/
    \nlumefantrine<\/li>\n
  • Antipsychotics: possibly inhibitsmetabolism of aripiprazole \u2013 reduce
    \ndose of aripiprazole; possibly increased
    \nconcentration of pimozide \u2013 avoid
    \nconcomitant use<\/li>\n
  • Antivirals: concentration reduced byefavirenz \u2013increase dose of atazanavir;
    \nconcentration possibly reduced by
    \nnevirapine \u2013 avoid concomitant use;
    \nsaquinavir concentration increased;
    \nconcentration reduced by tenofovir and
    \ntenofovir concentration possibly increased;
    \navoid concomitant use with indinavir
    \nC<\/li>\n
  • alcium-channel blockers: concentrationof diltiazem increased \u2013 reduce dose of
    \ndiltiazem; possibly increased verapamil
    \nconcentration<\/li>\n
  • Ciclosporin: possibly increasedconcentration of ciclosporin<\/li>\n
  • Cytotoxics: possibly inhibits metabolism ofirinotecan \u2013 increased risk of toxicity<\/li>\n
  • Ergot alkaloids: possibly increasedconcentration of ergot alkaloids \u2013 avoid
    \nconcomitant use
    \nOestrogens: increased concentration of<\/p>\n

    ethinylestradiol \u2013 avoid concomitant use
    \nSildenafil: possibly increased side effects<\/p>\n

    of sildenafil<\/li>\n

  • Sirolimus: possibly increasedconcentration of sirolimus
    \nStatins: avoid concomitant use with<\/p>\n

    simvastatin \u2013 increased risk of myopathy;
    \npossibly increased risk of myopathy with
    \natorvastatin
    \nt is not licensed for use by anyone else.<\/li>\n

  • Tacrolimus: possibly increasedconcentration of tacrolimus<\/li>\n
  • Ulcer-healing drugs: concentrationsignificantly reduced by omeprazole and
    \nesomeprazole and possibly other proton
    \npump inhibitors \u2013 avoid concomitant
    \nuse; concentration possibly reduced by
    \nhistamine H2 antagonists<\/p>\n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    Take with food<\/p>\n

    Comments<\/h4>\n

    Take didanosine 2 hours after atazanavir if<\/p>\n

    used in combination<\/li>\n","protected":false},"excerpt":{"rendered":"

    Atazanavir CLINICAL USE Protease inhibitor: HIV infection, in combination with<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1651","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1651","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1651"}],"version-history":[{"count":2,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1651\/revisions"}],"predecessor-version":[{"id":2947,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1651\/revisions\/2947"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1651"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1651"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1651"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}