{"id":1649,"date":"2023-06-25T17:29:04","date_gmt":"2023-06-25T17:29:04","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/ascorbic-acid\/"},"modified":"2023-06-25T19:59:27","modified_gmt":"2023-06-25T19:59:27","slug":"ascorbic-acid","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/ascorbic-acid\/","title":{"rendered":"Ascorbic acid"},"content":{"rendered":"

<\/p>\n

Ascorbic acid<\/h1>\n

CLINICAL USE<\/h3>\n
  • Acidification of urine<\/li>\n
  • Vitamin C deficiency
    \n

    DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

    Up to 4 g daily in divided doses<\/p>\n

    Prophylaxis: 25\u201375 mg daily<\/p>\n

    Therapeutic: 250 mg daily in divided doses<\/p>\n

    IV: 0.5\u20131 g daily<\/p>\n

    Preventative therapy: 200\u2013500 mg daily<\/p>\n

    PHARMACOKINETICS<\/h3>\n<\/li>\n
  • Molecular weight                           :
    \n176.1<\/li>\n
  • %Protein binding                           :
    \n25<\/li>\n
  • %Excreted unchanged in urine     :
    \nMinimal1<\/li>\n
  • Volume of distribution (L\/kg)       :
    \nNo data<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :
    \n3\u20134\/Unchanged<\/p>\n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           :
    \nDose as in normal renal function<\/p>\n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :
    \nDialysed. Dose as in normal renal
    \nfunction<\/li>\n
  • HD                     :
    \nDialysed. Dose as in normal renal
    \nfunction<\/li>\n
  • HDF\/high flux   :
    \nDialysed. Dose as in normal renal
    \nfunction<\/li>\n
  • CAV\/VVHD      :
    \nDialysed. Dose as in normal renal
    \nfunction<\/p>\n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs
    \nNone known<\/p>\n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral, IV<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n<\/li>\n
  • No scientific evidence from clinical trial ofefficacy in reducing UTI via acidification
    \nof urine<\/li>\n
  • In CKD 5 on dialysis, requirements areusually about 75\u201390 mg per day. (Kalanter-
    \nZadeh K, Kopple JD. Trace elements and
    \nvitamins in maintenance dialysis patients.<\/li>\n
  • Try to use lower doses in CKD 5 patientsdue to risk of oxalate formation<\/li>\n","protected":false},"excerpt":{"rendered":"

    Ascorbic acid CLINICAL USE Acidification of urine Vitamin C deficiency<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1649","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1649","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1649"}],"version-history":[{"count":2,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1649\/revisions"}],"predecessor-version":[{"id":2946,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1649\/revisions\/2946"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1649"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1649"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1649"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}