{"id":1643,"date":"2023-06-25T17:29:04","date_gmt":"2023-06-25T17:29:04","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/apomorphine-hydrochloride\/"},"modified":"2023-06-25T17:29:04","modified_gmt":"2023-06-25T17:29:04","slug":"apomorphine-hydrochloride","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/apomorphine-hydrochloride\/","title":{"rendered":"Apomorphine hydrochloride"},"content":{"rendered":"

<\/p>\n

Apomorphine hydrochloride<\/h1>\n

CLINICAL USE <\/H3>
\nTreatment of refractory motor fluctuations in
\nParkinson\u2019s disease
\n

DOSE IN NORMAL RENAL FUNCTION <\/H3>
\n3\u201330 mg daily in divided doses (maximum
\nsingle dose 10 mg); infusion: 1\u20134 mg\/hour
\nduring waking hours
\nMaximum dose 100 mg daily
\n

PHARMACOKINETICS <\/H3>
\n
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \n312.8\n<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \n90\n<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp :
    \n<2\n<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :
    \n2\u201319\n<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :
    \n29.1\u201336.9 minutes
    \n

    DOSE IN RENAL IMPAIRMENT <\/H3>
    \n

    GFR (mL\/MIN)<\/H4>
    \n
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function.
    \nStart with 1 mg
    \n
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function.
    \nStart with 1 mg
    \n
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : \nDose as in normal renal function. \nStart with 1 mg\n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
    \n
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:
    \nUnlikely to be dialysed. Dose as in
    \nGFR <10 mL\/min\n\n\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \nUnlikely to be dialysed. Dose as in
    \nGFR <10 mL\/min\n
  • HDF\/high flux &nbsp :
    \nUnlikely to be dialysed. Dose as in
    \nGFR <10 mL\/min\n
  • CAV\/VVHD &nbsp &nbsp &nbsp:
    \nUnlikely to be dialysed. Dose as in
    \nGFR 10 to 20 mL\/min
    \n

    IMPORTANT DRUG INTERACTIONS <\/H3>
    \nPotentially hazardous interactions with other drugs<\/p>\n
  • Nitrates: enhanced hypotensive effect\n
  • Antihypertensives: enhanced hypotensive\n

    effect
    \n

    ADMINISTRATION <\/H3>
    \n

    Reconstition<\/H4>
    \n\u2013
    \n

    Route <\/H4>
    \nSC<\/p>\n

    Rate of Administration <\/H4>
    \n1\u20134 mg\/hour<\/p>\n

    Comments<\/H4>
    \nChange site every 4 hours for SC <\/p>\n

    administration
    \n

    OTHER INFORMATION <\/H4><\/p>\n
  • Pre-treatment with domperidone is\n

    required for at least 2 days before and at
    \nleast 3 days after treatment<\/p>\n

  • Bioavailability by subcutaneous\n

    administration is 17\u201318%<\/p>\n

  • Most of dose is excreted in the urine as\n

    active metabolites<\/p>\n","protected":false},"excerpt":{"rendered":"

    Apomorphine hydrochloride CLINICAL USE Treatment of refractory motor fluctuations in<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1643","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1643","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1643"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1643\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1643"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1643"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1643"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}