{"id":1641,"date":"2023-06-25T17:29:04","date_gmt":"2023-06-25T17:29:04","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/anastrozole\/"},"modified":"2023-06-25T17:29:04","modified_gmt":"2023-06-25T17:29:04","slug":"anastrozole","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/anastrozole\/","title":{"rendered":"Anastrozole"},"content":{"rendered":"

<\/p>\n

Anastrozole<\/h1>\n

CLINICAL USE <\/H3>
\nTreatment of breast cancer in post-
\nmenopausal women
\n

DOSE IN NORMAL RENAL FUNCTION <\/H3>
\n1 mg daily
\n

PHARMACOKINETICS <\/H3>
\n
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \n293.4\n<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \n40\n<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp :
    \n
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp :\n<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :
    \nNo data\n<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :
    \n40\u201350\/Probably
    \nunchanged
    \n

    DOSE IN RENAL IMPAIRMENT <\/H3>
    \n

    GFR (mL\/MIN)<\/H4>
    \n
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
    \n
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
    \n
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : \nDose as in normal renal function\n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
    \n
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:
    \nDialysed. Dose as in normal renal
    \nfunction<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \nDialysed. Dose as in normal renal
    \nfunction
    \n
  • HDF\/high flux &nbsp :
    \nDialysed. Dose as in normal renal
    \nfunction
    \n
  • CAV\/VVHD &nbsp &nbsp &nbsp:
    \nDialysed. Dose as in normal renal
    \nfunction
    \n

    IMPORTANT DRUG INTERACTIONS <\/H3><\/p>\n
  • Potentially hazardous interactions with other drugs\n
  • Oestrogen-containing therapies: avoid\n

    concomitant administration as would
    \nnegate pharmacological action<\/p>\n

  • amoxifen: avoid concomitant\n

    administration
    \n

    ADMINISTRATION <\/H3>
    \n

    Reconstition<\/H4>
    \n\u2013
    \n

    Route <\/H4>
    \nOral<\/p>\n

    Rate of Administration <\/H4>
    \n\u2013
    \n

    Comments<\/H4>
    \n\u2013
    \n

    OTHER INFORMATION <\/H4><\/p>\n
  • Anastrozole is extensively metabolised in\n

    the liver; only 10% of unchanged drug and
    \n60% of metabolites (largely inactive) are
    \nexcreted in the urine<\/p>\n

  • Although renal clearance of anastrozole\n

    decreases proportionally with creatinine
    \nclearance, the reduction in renal clearance
    \ndoes not affect total body clearance of
    \nanastrozole. According to the American
    \nSPC a dose reduction is not required in
    \nrenal impairment<\/p>\n

  • In the UK, the SPC recommends avoiding\n

    the use of anastrozole in patients with
    \nGFR<20 mL\/min\n\n\n\n \n<\/p>\n","protected":false},"excerpt":{"rendered":"

    Anastrozole CLINICAL USE Treatment of breast cancer in post- menopausal<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1641","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1641","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1641"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1641\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1641"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1641"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1641"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}