{"id":1640,"date":"2023-06-25T17:29:04","date_gmt":"2023-06-25T17:29:04","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/anagrelide\/"},"modified":"2023-06-25T17:29:04","modified_gmt":"2023-06-25T17:29:04","slug":"anagrelide","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/anagrelide\/","title":{"rendered":"Anagrelide"},"content":{"rendered":"

<\/p>\n

Anagrelide<\/h1>\n

CLINICAL USE <\/H3>
\nPlatelet-reducing agent
\n

DOSE IN NORMAL RENAL FUNCTION <\/H3>
\n1\u201310 mg daily in divided doses; maximum
\nsingle dose 2.5 mg; normal range 1\u20133 mg
\ndaily
\n

PHARMACOKINETICS <\/H3>
\n
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \n292.5 (as
    \nhydrochloride)\n<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \nNo data\n<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp :
    \n<1\n<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :
    \n12\n<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :
    \n1.3
    \n

    DOSE IN RENAL IMPAIRMENT <\/H3>
    \n

    GFR (mL\/MIN)<\/H4>
    \n30\u201350 Dose as in normal renal function
    \n10\u201330 Dose as in normal renal function,
    \nbut use with caution and keep to
    \nlowest dose possible
    \n
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : \nDose as in normal renal function, \nbut use with caution and keep to \nlowest dose possible\n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
    \n
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:
    \nUnknown dialysability. Dose as in
    \nGFR <10 mL\/min\n\n\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    \nUnknown dialysability. Dose as in
    \nGFR <10 mL\/min\n
  • HDF\/high flux &nbsp :
    \nUnknown dialysability. Dose as in
    \nGFR <10 mL\/min\n
  • CAV\/VVHD &nbsp &nbsp &nbsp:
    \nUnknown dialysability. Dose as in
    \nGFR=10\u201330 mL\/min
    \n

    IMPORTANT DRUG INTERACTIONS <\/H3>
    \nPotentially hazardous interactions with other drugs<\/p>\n
  • Cilostazol: avoid concomitant use\n

    Phosphodiesterase inhibitors: avoid <\/p>\n

    concomitant use with milrinone and
    \nenoximone<\/p>\n

  • spirin: potential risks and benefits must\n

    first be assessed, additive antiplatelet effect<\/p>\n

  • Grapefruit juice: may reduce clearance of\n

    anagrelide
    \n

    ADMINISTRATION <\/H3>
    \n

    Reconstition<\/H4>
    \n\u2013
    \n

    Route <\/H4>
    \nOral<\/p>\n

    Rate of Administration <\/H4>
    \n\u2013
    \n

    Comments<\/H4>
    \n\u2013
    \n

    OTHER INFORMATION <\/H4><\/p>\n
  • May cause fluid retention, tachycardia and\n

    various cardiac complications<\/p>\n

  • Rarely can increase creatinine levels\n
  • High doses can cause a drop in blood\n

    pressure<\/p>\n","protected":false},"excerpt":{"rendered":"

    Anagrelide CLINICAL USE Platelet-reducing agent DOSE IN NORMAL RENAL FUNCTION<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1640","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1640","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1640"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1640\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1640"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1640"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1640"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}