{"id":1637,"date":"2023-06-25T17:28:42","date_gmt":"2023-06-25T17:28:42","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/ampicillin2\/"},"modified":"2023-06-25T19:58:47","modified_gmt":"2023-06-25T19:58:47","slug":"ampicillin2","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/ampicillin2\/","title":{"rendered":"Ampicillin2"},"content":{"rendered":"

<\/p>\n

Ampicillin<\/h1>\n

CLINICAL USE<\/h3>\n

Antibacterial agent<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

Oral: 250 mg \u2013 1 g every 6 hours
\nIM\/IV: 500 mg \u2013 2 g every 4\u20136 hours<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           :
    \n349.4<\/li>\n
  • %Protein binding                           :
    \n20<\/li>\n
  • %Excreted unchanged in urine     :
    \nOral: 20\u201360;
    \nParenteral: 60\u201380<\/li>\n
  • Volume of distribution (L\/kg)       :
    \n0.17\u20130.31<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :
    \n1\u20131.5\/7\u201320<\/p>\n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : 250 mg \u2013 2 g every 6 hours<\/li>\n
  • <10           :
    \n250 mg \u20131 g every 6 hours<\/p>\n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :
    \nNot dialysed. Dose as in
    \nGFR <10 mL\/min<\/li>\n
  • HD                     :
    \nDialysed. Dose as in GFR<\/li>\n
  • <10           : mL\/
    \nmin<\/li>\n
  • HDF\/high flux   :
    \nDialysed. Dose as in GFR<\/li>\n
  • <10           : mL\/
    \nmin<\/li>\n
  • CAV\/VVHD      :
    \nDialysed. Dose as in GFR=10\u2013
    \n20 mL\/min<\/p>\n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs
    \nCiclosporin: may increase ciclosporin<\/p>\n

    levels
    \nReduces excretion of methotrexate<\/p>\n

    (increased risk of toxicity)<\/p>\n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    Use water for injection: 5 mL for each<\/p>\n

    250 mg (1.5 mL for 250 mg or 500 mg for
    \nIM administration)<\/p>\n

    Route<\/h4>\n

    Oral, IV, IM<\/p>\n

    Rate of Administration<\/h4>\n

    Slow IV bolus over 3\u20134 minutes. Doses<\/p>\n

    greater than 500 mg should be given by
    \ninfusion<\/p>\n

    Comments<\/h4>\n

    Can be diluted in glucose 5% or sodium<\/p>\n

    chloride 0.9%<\/p>\n

    OTHER INFORMATION<\/h4>\n<\/li>\n
  • Rashes more common in patients withrenal impairment<\/li>\n
  • Can cause nephrotoxicity if dose notreduced in renal impairment<\/li>\n
  • Sodium content of injection1.47 mmol\/500 mg vial<\/li>\n
  • Ampicillin may be used in peritonealdialysis fluids for treatment of peritonitis
    \nDo not mix with aminoglycosides<\/li>\n","protected":false},"excerpt":{"rendered":"

    Ampicillin CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL FUNCTION<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1637","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1637","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1637"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1637\/revisions"}],"predecessor-version":[{"id":2932,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1637\/revisions\/2932"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1637"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1637"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1637"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}