{"id":1634,"date":"2023-06-25T17:28:42","date_gmt":"2023-06-25T17:28:42","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/amoxicillin\/"},"modified":"2023-06-25T19:58:38","modified_gmt":"2023-06-25T19:58:38","slug":"amoxicillin","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/amoxicillin\/","title":{"rendered":"Amoxicillin"},"content":{"rendered":"

<\/p>\n

Amoxicillin<\/h1>\n

CLINICAL USE<\/h3>\n

Antibacterial agent<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

250 mg \u2013 1 g every 8 hours (maximum 6 g per
\nday, up to 12 g in endocarditis)<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           :
    \n365.4<\/li>\n
  • %Protein binding                           :
    \n20<\/li>\n
  • %Excreted unchanged in urine     :
    \n60<\/li>\n
  • Volume of distribution (L\/kg)       :
    \n0.3<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :
    \n1\u20131.5\/7\u201320<\/p>\n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           :
    \n250 mg \u2013 1 g every 8 hours
    \n(Maximum 6 g per day in
    \nendocarditis)<\/p>\n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :
    \nNot dialysed. Dose as in
    \nGFR <10 mL\/min<\/li>\n
  • HD                     :
    \nDialysed. Dose as in GFR<\/li>\n
  • <10           : mL\/
    \nmin<\/li>\n
  • HDF\/high flux   :
    \nDialysed. Dose as in GFR<\/li>\n
  • <10           : mL\/
    \nmin<\/li>\n
  • CAV\/VVHD      :
    \nDialysed. Dose as in normal renal
    \nfunction<\/p>\n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Amoxicillin can reduce the excretion ofmethotrexate (increased risk of toxicity)
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n<\/li>\n
  • IV: Dissolve each 250 mg in 5 mL water forinjection<\/li>\n
  • IV Infusion: Dilute in 100 mL glucose 5%or sodium chloride 0.9%<\/li>\n
  • IM: Dissolve 250 mg in 1.5 mL water forinjection; 500 mg in 2.5 mL water for
    \ninjection; 1 g in 2.5 mL water for injection
    \nor 1% sterile lidocaine hydrochloride<\/p>\n

    Route<\/h4>\n

    Oral, IV, IM<\/p>\n

    Rate of Administration<\/h4>\n<\/li>\n
  • Slow bolus IV over 3\u20134 minutes<\/li>\n
  • Infusion over 30\u201360 minutes
    \n

    Comments<\/h4>\n

    Stability in infusion depends upon diluent<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Sodium \u2013 3.3 mmol\/g vial of Amoxil<\/p>\n

    Do not mix with aminoglycosides<\/li>\n","protected":false},"excerpt":{"rendered":"

    Amoxicillin CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL FUNCTION<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1634","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1634","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1634"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1634\/revisions"}],"predecessor-version":[{"id":2929,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1634\/revisions\/2929"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1634"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1634"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1634"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}