{"id":1633,"date":"2023-06-25T17:28:42","date_gmt":"2023-06-25T17:28:42","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/amlodipine\/"},"modified":"2023-06-25T19:58:34","modified_gmt":"2023-06-25T19:58:34","slug":"amlodipine","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/amlodipine\/","title":{"rendered":"Amlodipine"},"content":{"rendered":"

<\/p>\n

Amlodipine<\/h1>\n

CLINICAL USE<\/h3>\n

Calcium-channel blocker:<\/p>\n

  • Hypertension<\/li>\n
  • Angina prophylaxis
    \n

    DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

    5\u201310 mg daily<\/p>\n

    PHARMACOKINETICS<\/h3>\n<\/li>\n
  • Molecular weight                           :
    \n567.1 (as besilate)<\/li>\n
  • %Protein binding                           :
    \n>95<\/li>\n
  • %Excreted unchanged in urine     :<\/li>\n
  • <10           :<\/li>\n
  • Volume of distribution (L\/kg)       :
    \n20<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :
    \n35\u201350\/50<\/p>\n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           :
    \nDose as in normal renal function<\/p>\n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :
    \nNot dialysed. Dose as in normal renal function<\/li>\n
  • HD                     :
    \nNot dialysed. Dose as in normal renal function<\/li>\n
  • HDF\/high flux   :
    \nUnlikely to be dialysed. Dose as in
    \nnormal renal function<\/li>\n
  • CAV\/VVHD      :
    \nNot dialysed. Dose as in normal renal function<\/p>\n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Anaesthetics: enhanced hypotensive effect<\/li>\n
  • Antihypertensives: enhanced hypotensiveeffect; increased risk of first dose
    \nhypotensive effect of post-synaptic alpha-
    \nblockers<\/li>\n
  • Antivirals: concentration possiblyincreased by ritonavir
    \nTheophylline: possibly increased<\/p>\n

    theophylline concentration<\/p>\n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Amlodipine is extensively metabolised to<\/p>\n

    inactive metabolites<\/li>\n","protected":false},"excerpt":{"rendered":"

    Amlodipine CLINICAL USE Calcium-channel blocker: Hypertension Angina prophylaxis DOSE IN<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1633","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1633","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1633"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1633\/revisions"}],"predecessor-version":[{"id":2928,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1633\/revisions\/2928"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1633"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1633"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1633"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}