{"id":1628,"date":"2023-06-25T17:28:42","date_gmt":"2023-06-25T17:28:42","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/amiloride-hydrochloride\/"},"modified":"2023-06-25T19:58:50","modified_gmt":"2023-06-25T19:58:50","slug":"amiloride-hydrochloride","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/amiloride-hydrochloride\/","title":{"rendered":"Amiloride hydrochloride"},"content":{"rendered":"

<\/p>\n

Amiloride hydrochloride<\/h1>\n

CLINICAL USE<\/h3>\n
  • Oedema<\/li>\n
  • Potassium conservation with thiazide andloop diuretics
    \n

    DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

    5\u201310 mg daily; maximum 20 mg daily<\/p>\n

    PHARMACOKINETICS<\/h3>\n<\/li>\n
  • Molecular weight                           :
    \n302.1<\/li>\n
  • %Protein binding                           :
    \n30\u201340<\/li>\n
  • %Excreted unchanged in urine     :
    \n50<\/li>\n
  • Volume of distribution (L\/kg)       :
    \n5<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :
    \n6\u201320\/100<\/p>\n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Use 50% of dose<\/li>\n
  • 10 to 20     : Use 50% of dose<\/li>\n
  • <10           :
    \nAvoid<\/p>\n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :
    \nNot applicable. Avoid<\/li>\n
  • HD                     :
    \nNot applicable. Avoid<\/li>\n
  • HDF\/high flux   :
    \nNot applicable. Avoid<\/li>\n
  • CAV\/VVHD      :
    \nUnknown dialysability. Dose as in
    \nGFR 10 to 20 mL\/min<\/p>\n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • ACE inhibitor and angiotensin-II antagonists: increased risk of
    \nhyperkalaemia and hypotension
    \nAntibacterials: avoid concomitant use with<\/p>\n

    lymecycline<\/li>\n

  • Antidepressants: increased risk of posturalhypotension with tricyclics; enhanced
    \nhypotensive effect with MAOIs
    \nAntihypertensives: enhanced hypotensive<\/p>\n

    effect<\/li>\n

  • Ciclosporin: increased risk ofhyperkalaemia and nephrotoxicity
    \nLithium excretion reduced<\/li>\n
  • NSAIDS: increased risk of hyperkalaemia;increased risk of<\/li>\n
  • nephrotoxicity;
    \nantagonism of diuretic effect<\/li>\n
  • Potassium salts: increased risk ofhyperkalaemia<\/li>\n
  • Tacrolimus: increased risk ofhyperkalaemia
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n<\/li>\n
  • Monitor for hyperkalaemia<\/li>\n
  • Greatly increased risk of hyperkalaemia inpatients with a GFR<30 mL\/min, especially
    \nin diabetics<\/li>\n
  • Increased risk of hyperchloraemic\n

    metabolic acidosis in patients with
    \nreduced GFR<\/li>\n

  • Bioavailability is 50% and can be reducedby administering with food<\/li>\n
  • Reduced natriuretic effect once theGFR<50 mL\/min<\/li>\n
  • Diuretic effect starts 2 hours after\n

    administration, peaks after 6\u201310 hours
    \nand can last up to 24 hours<\/li>\n","protected":false},"excerpt":{"rendered":"

    Amiloride hydrochloride CLINICAL USE Oedema Potassium conservation with thiazide andloop<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1628","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1628","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1628"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1628\/revisions"}],"predecessor-version":[{"id":2933,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1628\/revisions\/2933"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1628"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1628"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1628"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}