{"id":1625,"date":"2023-06-25T17:28:42","date_gmt":"2023-06-25T17:28:42","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/amantadine-hydrochloride\/"},"modified":"2023-06-25T19:59:15","modified_gmt":"2023-06-25T19:59:15","slug":"amantadine-hydrochloride","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/amantadine-hydrochloride\/","title":{"rendered":"Amantadine hydrochloride"},"content":{"rendered":"

<\/p>\n

Amantadine hydrochloride<\/h1>\n

CLINICAL USE<\/h3>\n
  • Parkinson\u2019s disease (but not drug inducedextrapyramidal symptoms)<\/li>\n
  • Post-herpetic neuralgia<\/li>\n
  • Prophylaxis and treatment of influenza A
    \n

    DOSE IN NORMAL RENAL FUNCTION<\/h3>\n<\/li>\n
  • Parkinson\u2019s disease: 100 mg once a day,increased after one week to 100\u2013200 mg
    \ntwice a day<\/li>\n
  • Post-herpetic neuralgia: 100 mg twice aday for 14 days<\/li>\n
  • Influenza A: treatment \u2013 100 mg once aday for 4\u20135 days; prophylaxis \u2013 100 mg
    \nonce a day<\/p>\n

    PHARMACOKINETICS<\/h3>\n<\/li>\n
  • Molecular weight                           :
    \n187.7<\/li>\n
  • %Protein binding                           :
    \n67<\/li>\n
  • %Excreted unchanged in urine     :
    \n90<\/li>\n
  • Volume of distribution (L\/kg)       :
    \n5\u201310<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :
    \n15\/500<\/p>\n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n

    35\u201350 100 mg every 24 hours
    \n15\u201335 100 mg every 48\u201372 hours
    \n<15
    \n100 mg every 7 days<\/p>\n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :
    \nNot dialysed. Dose as in
    \nGFR <10 mL\/min<\/li>\n
  • HD                     :
    \nNot dialysed. Dose as in
    \nGFR <10 mL\/min<\/li>\n
  • HDF\/high flux   :
    \nUnknown dialysability. Dose as in
    \nGFR<15 mL\/min<\/li>\n
  • CAV\/VVHD      :
    \nUnknown dialysability. Dose as in
    \nGFR=15\u201335 mL\/min<\/p>\n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Memantine: increased risk of CNStoxicity \u2013 avoid concomitant use; effects of
    \namantadine possibly enhanced<\/p>\n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n<\/li>\n
  • Peripheral oedema may occur in somepatients; should be considered when
    \nthe drug is prescribed for those with
    \ncongestive heart failure<\/li>\n
  • Side effects are often mild and transient;usually appear within 2\u20134 days of
    \ntreatment and disappear 24\u201348 hours after
    \ndiscontinuation of the drug<\/li>\n
  • Due to extensive tissue binding, <5% of a\n

    dose is removed by a 4 hour haemodialysis
    \nsession<\/li>\n

  • A reduction in creatinine clearance to40 mL\/min may result in a 5-fold increase
    \nin elimination half-life<\/li>\n","protected":false},"excerpt":{"rendered":"

    Amantadine hydrochloride CLINICAL USE Parkinson\u2019s disease (but not drug inducedextrapyramidal<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1625","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1625","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1625"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1625\/revisions"}],"predecessor-version":[{"id":2942,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1625\/revisions\/2942"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1625"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1625"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1625"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}