{"id":1622,"date":"2023-06-25T17:28:42","date_gmt":"2023-06-25T17:28:42","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/almotriptan\/"},"modified":"2023-06-25T19:59:06","modified_gmt":"2023-06-25T19:59:06","slug":"almotriptan","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/almotriptan\/","title":{"rendered":"Almotriptan"},"content":{"rendered":"

<\/p>\n

Almotriptan<\/h1>\n

CLINICAL USE<\/h3>\n

Acute relief of migraine<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

12.5 mg repeated after 2 hours if migraine
\nrecurs (do not take 2nd dose for the same
\nattack)
\nMaximum 25 mg in 24 hours<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           :
    \n469.6 (as malate)<\/li>\n
  • %Protein binding                           :
    \n35<\/li>\n
  • %Excreted unchanged in urine     :
    \n40\u201350<\/li>\n
  • Volume of distribution (L\/kg)       :
    \n195 litres<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :
    \n3.5\/7<\/p>\n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n

    30\u201350 Dose as in normal renal function
    \n10\u201330 6.25 mg; maximum daily dose
    \n12.5 mg. Use with caution<\/li>\n

  • <10           :
    \n6.25 mg; maximum daily dose
    \n12.5 mg. Use with caution<\/p>\n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :
    \nUnknown dialysability. Dose as in
    \nGFR <10 mL\/min<\/li>\n
  • HD                     :
    \nLikely dialysability. Dose as in
    \nGFR <10 mL\/min<\/li>\n
  • HDF\/high flux   :
    \nLikely dialysability. Dose as in
    \nGFR <10 mL\/min<\/li>\n
  • CAV\/VVHD      :
    \nUnknown dialysability. Dose as in
    \nGFR=10\u201330 mL\/min<\/p>\n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Antidepressants: possibly increasedserotonergic effects with duloxetine;
    \nincreased serotonergic effects with St
    \nJohn\u2019s wort \u2013 avoid concomitant use<\/li>\n
  • Antifungals: concentration increased byketoconazole (increased risk of toxicity)<\/li>\n
  • Ergot alkaloids: increased risk ofvasospasm
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/li>\n","protected":false},"excerpt":{"rendered":"

    Almotriptan CLINICAL USE Acute relief of migraine DOSE IN NORMAL<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1622","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1622","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1622"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1622\/revisions"}],"predecessor-version":[{"id":2939,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1622\/revisions\/2939"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1622"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1622"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1622"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}