{"id":1620,"date":"2023-06-25T17:28:42","date_gmt":"2023-06-25T17:28:42","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/aliskiren-fumarate\/"},"modified":"2023-06-25T19:59:02","modified_gmt":"2023-06-25T19:59:02","slug":"aliskiren-fumarate","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/aliskiren-fumarate\/","title":{"rendered":"Aliskiren fumarate"},"content":{"rendered":"

<\/p>\n

Aliskiren fumarate<\/h1>\n

CLINICAL USE<\/h3>\n

Renin inhibitor, used for hypertension and
\ndiabetic nephropathy<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

150\u2013300 mg once daily<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           :
    \n1219.6<\/li>\n
  • %Protein binding                           :
    \n47\u201351<\/li>\n
  • %Excreted unchanged in urine     :
    \n0.6<\/li>\n
  • Volume of distribution (L\/kg)       :
    \n135 litres<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :
    \n34\u201341\/Unchanged<\/p>\n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           :
    \nDose as in normal renal function<\/p>\n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :
    \nUnlikely to be dialysed. Dose as in
    \nnormal renal function<\/li>\n
  • HD                     :
    \nUnlikely to be dialysed. Dose as in
    \nnormal renal function<\/li>\n
  • HDF\/high flux   :
    \nUnlikely to be dialysed. Dose as in
    \nnormal renal function<\/li>\n
  • CAV\/VVHD      :
    \nUnlikely to be dialysed. Dose as in
    \nnormal renal function<\/p>\n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Other antihypertensive agents: enhancedantihypertensive effect; concentration
    \npossibly reduced by irbesartan<\/li>\n
  • Antifungals: plasma concentration ofaliskiren increased by ketoconazole<\/li>\n
  • Diuretics: may reduce concentrationof furosemide; hyperkalaemia with
    \npotassium-sparing diuretics<\/li>\n
  • Heparins: increased risk of hyperkalaemia<\/li>\n
  • Potassium salts: increased risk ofhyperkalaemia
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n<\/li>\n
  • Potassium should be monitored in patientswith renal impairment, diabetes or heart
    \nfailure<\/li>\n
  • Oral bioavailability is only 2\u20133%<\/li>\n","protected":false},"excerpt":{"rendered":"

    Aliskiren fumarate CLINICAL USE Renin inhibitor, used for hypertension and<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1620","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1620","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1620"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1620\/revisions"}],"predecessor-version":[{"id":2937,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1620\/revisions\/2937"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1620"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1620"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1620"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}