{"id":1615,"date":"2023-06-25T17:27:16","date_gmt":"2023-06-25T17:27:16","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/albendazole\/"},"modified":"2023-06-25T19:56:51","modified_gmt":"2023-06-25T19:56:51","slug":"albendazole","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/albendazole\/","title":{"rendered":"Albendazole"},"content":{"rendered":"

<\/p>\n

Albendazole<\/h1>\n

CLINICAL USE<\/h3>\n
  • Treatment ofEchinococcus granulosus
    \n(hydatid disease), in combination with
    \nsurgery<\/li>\n
  • Treatment of nematode infections
    \n

    DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

    Echinococcus granulosus:<\/li>\n

  • >60 kg: 400 mg twice daily for 28 days<\/li>\n
  • <60 kg: 15 mg\/kg in 2 divided doses to amaximum of 800 mg daily
    \nTreatment of nematode infections: 400 mg as
    \na single dose<\/p>\n

    PHARMACOKINETICS<\/h3>\n<\/li>\n
  • Molecular weight                           :
    \n265.3<\/li>\n
  • %Protein binding                           :
    \n70<\/li>\n
  • %Excreted unchanged in urine     :
    \n<1<\/li>\n
  • Volume of distribution (L\/kg)       :
    \nNo data<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :
    \n8\u201312 (metabolite)\/
    \nProbably unchanged<\/p>\n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           :
    \nDose as in normal renal function<\/p>\n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :
    \nUnlikely dialysability. Dose as in
    \nnormal renal function<\/li>\n
  • HD                     :
    \nNot dialysed. Dose as in normal renal function<\/li>\n
  • HDF\/high flux   :
    \nUnknown dialysability. Dose as in
    \nnormal renal function<\/li>\n
  • CAV\/VVHD      :
    \nUnlikely dialysability. Dose as in
    \nnormal renal function<\/p>\n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs
    \nDexamethasone: increased concentrations<\/p>\n

    of metabolite of albendazole<\/p>\n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Available on a named patient basis from<\/p>\n

    IDIS (Zentel\u00ae)
    \nUndergoes first pass metabolism<\/li>\n","protected":false},"excerpt":{"rendered":"

    Albendazole CLINICAL USE Treatment ofEchinococcus granulosus (hydatid disease), in combination<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1615","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1615","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1615"}],"version-history":[{"count":2,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1615\/revisions"}],"predecessor-version":[{"id":2913,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1615\/revisions\/2913"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1615"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1615"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1615"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}