{"id":1614,"date":"2023-06-25T17:27:16","date_gmt":"2023-06-25T17:27:16","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/adrenaline\/"},"modified":"2023-06-25T19:56:28","modified_gmt":"2023-06-25T19:56:28","slug":"adrenaline","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/adrenaline\/","title":{"rendered":"Adrenaline"},"content":{"rendered":"

<\/p>\n

Adrenaline<\/h1>\n

CLINICAL USE<\/h3>\n

Sympathomimetic and inotropic agent<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

1\u201320 micrograms\/minute<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           :
    \n183.2<\/li>\n
  • %Protein binding                           :
    \n50<\/li>\n
  • %Excreted unchanged in urine     :
    \n1<\/li>\n
  • Volume of distribution (L\/kg)       :
    \nNo data<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :
    \nPhase 1: 3 minutes;
    \nPhase 2: 10 minutes<\/p>\n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function<\/li>\n
  • <10           :
    \nDose as in normal renal function<\/p>\n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :
    \nNot dialysed. Dose as in normal renal function<\/li>\n
  • HD                     :
    \nNot dialysed. Dose as in normal renal function<\/li>\n
  • HDF\/high flux   :
    \nUnknown dialysability. Dose as in
    \nnormal renal function<\/li>\n
  • CAV\/VVHD      :
    \nNot dialysed. Dose as in normal renal function<\/p>\n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Alpha-blockers: avoid with tolazoline<\/li>\n
  • Anaesthetics: increased risk ofarrhythmias if given with volatile
    \nanaesthetics<\/li>\n
  • Antidepressants: increased risk ofarrhythmias and hypertension if given
    \nwith tricyclics; MAOIs and moclobemide
    \nmay cause hypertensive crisis.<\/li>\n
  • Beta-blockers: increased risk of severehypertension<\/li>\n
  • Clonidine: possible increased risk ofhypertension
    \nDopaminergics: effects possibly increased<\/p>\n

    by entacapone; avoid concomitant use
    \nwith rasagiline<\/li>\n

  • Sympathomimetics: effects possiblyenhanced by dopexamine
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n<\/li>\n
  • 1 mg in 100 mL glucose 5%<\/li>\n
  • 6 mL\/hour = 1 microgram\/minute \u2013according to local protocol
    \n

    Route<\/h4>\n

    IV, IM, SC<\/p>\n

    Rate of Administration<\/h4>\n

    Monitor blood pressure and adjust dose<\/p>\n

    according to response<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Catecholamines have a high non-renal<\/p>\n

    systemic clearance; therefore the effect of
    \nany renal replacement therapy is unlikely
    \nto be relevant<\/li>\n","protected":false},"excerpt":{"rendered":"

    Adrenaline CLINICAL USE Sympathomimetic and inotropic agent DOSE IN NORMAL<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1614","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1614","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1614"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1614\/revisions"}],"predecessor-version":[{"id":2912,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1614\/revisions\/2912"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1614"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1614"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1614"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}