{"id":1612,"date":"2023-06-25T17:27:16","date_gmt":"2023-06-25T17:27:16","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/adefovir-dipivoxil\/"},"modified":"2023-06-25T19:56:08","modified_gmt":"2023-06-25T19:56:08","slug":"adefovir-dipivoxil","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/adefovir-dipivoxil\/","title":{"rendered":"Adefovir dipivoxil"},"content":{"rendered":"

<\/p>\n

Adefovir dipivoxil<\/h1>\n

CLINICAL USE<\/h3>\n

Treatment of chronic hepatitis B infection<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

10 mg once daily<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           :
    \n501.5<\/li>\n
  • %Protein binding                           :
    \n<4<\/li>\n
  • %Excreted unchanged in urine     :
    \n45<\/li>\n
  • Volume of distribution (L\/kg)       :
    \n0.4<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :
    \n7\/15<\/p>\n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : 10 mg every 48 hours<\/li>\n
  • 10 to 20     : 10 mg every 72 hours<\/li>\n
  • <10           :
    \n10 mg every 72 hours<\/p>\n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :
    \nUnknown dialysability. Dose as in
    \nGFR <10 mL\/min<\/li>\n
  • HD                     :
    \nDialysed. 10 mg weekly or after
    \na cumulative total of 12 hours
    \ndialysis. See \u2018Other Information\u2019<\/li>\n
  • HDF\/high flux   :
    \nDialysed. Dose as in GFR<\/li>\n
  • <10           : mL\/
    \nmin<\/li>\n
  • CAV\/VVHD      :
    \nUnknown dialysability. Dose as in
    \nGFR 10 to 20 mL\/min<\/p>\n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Use with caution in combination withother nephrotoxins
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n<\/li>\n
  • Nephrotoxic in higher IV doses, but riskis lower with oral doses; although cases
    \nof raised creatinine and ARF have been
    \nreported<\/li>\n
  • Discontinue treatment if any of thefollowing occur: lactic acidosis, rapid
    \nincrease in aminotransferase, progressive
    \nhepatomegaly or steatosis<\/li>\n
  • 35% of dose is removed with a 4 hourdialysis session<\/li>\n
  • Administered as a prodrug converted toadefovir<\/li>\n","protected":false},"excerpt":{"rendered":"

    Adefovir dipivoxil CLINICAL USE Treatment of chronic hepatitis B infection<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1612","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1612","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1612"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1612\/revisions"}],"predecessor-version":[{"id":2910,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1612\/revisions\/2910"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1612"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1612"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1612"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}