{"id":1610,"date":"2023-06-25T17:27:16","date_gmt":"2023-06-25T17:27:16","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/acitretin\/"},"modified":"2023-06-25T19:55:46","modified_gmt":"2023-06-25T19:55:46","slug":"acitretin","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/acitretin\/","title":{"rendered":"Acitretin"},"content":{"rendered":"

<\/p>\n

Acitretin<\/h1>\n

CLINICAL USE<\/h3>\n
  • Severe extensive psoriasis, palmoplantarpustular psoriasis<\/li>\n
  • Severe congenital ichthyosis<\/li>\n
  • Severe Darier\u2019s disease
    \n

    DOSE IN NORMAL RENAL FUNCTION<\/h3>\n<\/li>\n
  • Initially: 25\u201330 mg daily (Darier\u2019s disease10 mg daily) for 2\u20134 weeks, adjusted
    \naccording to response<\/li>\n
  • Ongoing: usually 25\u201350 mg\/day(maximum 75 mg) for further 6\u20138 weeks.
    \n(In Darier\u2019s disease and ichthyosis not
    \nmore than 50 mg daily for up to 6 months)<\/p>\n

    PHARMACOKINETICS<\/h3>\n<\/li>\n
  • Molecular weight                           :
    \n326.4<\/li>\n
  • %Protein binding                           :
    \n>99 (< 0.1% present
    \nas unbound drug
    \nin pooled human
    \nplasma)<\/li>\n
  • %Excreted unchanged in urine     :
    \nExcreted as
    \nmetabolites<\/li>\n
  • Volume of distribution (L\/kg)       :
    \n9<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :
    \n50\/\u2013<\/p>\n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : No data available. Assume dose as in
    \nnormal renal function<\/li>\n
  • 10 to 20     : No data available. Assume dose as in
    \nnormal renal function<\/li>\n
  • <10           :
    \nNo data available. Assume dose as in
    \nnormal renal function<\/p>\n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :
    \nUnlikely to be dialysed. Dose as in
    \nnormal renal function<\/li>\n
  • HD                     :
    \nNot dialysed. Dose as in normal renal function<\/li>\n
  • HDF\/high flux   :
    \nUnlikely to be dialysed. Dose as in
    \nnormal renal function<\/li>\n
  • CAV\/VVHD      :
    \nUnknown dialysability. Dose as in
    \nnormal renal function<\/p>\n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Antibacterials: possibly increased risk ofbenign intracranial hypertension with
    \ntetracyclines \u2013 avoid concomitant use<\/li>\n
  • Anticoagulants: possible antagonism of theanticoagulant effect of coumarins<\/li>\n
  • Cytotoxics: increased concentrationof methotrexate (also increased risk of
    \nhepatotoxicity) \u2013 avoid concomitant use<\/p>\n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    Take once daily with meals or with milk<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Manufacturer\u2019s literature contraindicates<\/p>\n

    the use of acitretin in renal failure<\/li>\n","protected":false},"excerpt":{"rendered":"

    Acitretin CLINICAL USE Severe extensive psoriasis, palmoplantarpustular psoriasis Severe congenital<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1610","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1610","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1610"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1610\/revisions"}],"predecessor-version":[{"id":2908,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1610\/revisions\/2908"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1610"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1610"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1610"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}