{"id":1609,"date":"2023-06-25T17:27:16","date_gmt":"2023-06-25T17:27:16","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/acipimox\/"},"modified":"2023-06-25T19:55:34","modified_gmt":"2023-06-25T19:55:34","slug":"acipimox","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/acipimox\/","title":{"rendered":"Acipimox"},"content":{"rendered":"

<\/p>\n

Acipimox<\/h1>\n

CLINICAL USE<\/h3>\n

Hyperlipidaemia<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

250 mg 2 or 3 times daily<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           :
    \n154.1<\/li>\n
  • %Protein binding                           :
    \n0<\/li>\n
  • %Excreted unchanged in urine     :
    \n86\u201390<\/li>\n
  • Volume of distribution (L\/kg)       :
    \n0.3\u20130.4<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :
    \n2\/Increased<\/p>\n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n

    40\u201380 250 mg daily
    \n20\u201340 250 mg alternate days.
    \n<20
    \nSee \u2018Other Information\u2019<\/p>\n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :
    \nLikely dialysability. Dose as in
    \nGFR<20 mL\/min<\/li>\n
  • HD                     :
    \nDialysed. Dose as in
    \nGFR<20 mL\/min<\/li>\n
  • HDF\/high flux   :
    \nDialysed. Dose as in
    \nGFR<20 mL\/min<\/li>\n
  • CAV\/VVHD      :
    \nDialysed. Dose as in
    \nGFR=20\u201340 mL\/min<\/p>\n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • None known
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    Take with or after meals<\/p>\n

    OTHER INFORMATION<\/h4>\n<\/li>\n
  • Females are twice as likely as males tosuffer from side effects, e.g. flushing,
    \npruritus and skin rashes<\/li>\n
  • Doses up to 1200 mg have been givensafely for long periods
    \nAfter a 5 hour dialysis 70% of the drug had<\/p>\n

    been removed<\/li>\n

  • Dollery advises the doses given in thetable, down to 20 mL\/minute, but nothing
    \nafter that.
    \nMicromedex gives the following<\/p>\n

    recommendations:
    \nGFR: 30\u201360 mL\/min 150 mg twice daily
    \nGFR: 10\u201330 mL\/min 150 mg once daily
    \nGFR:<\/li>\n

  • <10           : mL\/min 150 mg alternate days<\/li>\n","protected":false},"excerpt":{"rendered":"

    Acipimox CLINICAL USE Hyperlipidaemia DOSE IN NORMAL RENAL FUNCTION 250<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1609","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1609","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1609"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1609\/revisions"}],"predecessor-version":[{"id":2907,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1609\/revisions\/2907"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1609"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1609"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1609"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}