{"id":1608,"date":"2023-06-25T17:27:16","date_gmt":"2023-06-25T17:27:16","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/aciclovir-oral\/"},"modified":"2023-06-25T19:57:25","modified_gmt":"2023-06-25T19:57:25","slug":"aciclovir-oral","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/aciclovir-oral\/","title":{"rendered":"Aciclovir oral"},"content":{"rendered":"

<\/p>\n

Aciclovir oral<\/h1>\n

CLINICAL USE<\/h3>\n

Antiviral agent:<\/p>\n

  • Herpes simplex and herpes zoster infection
    \n

    DOSE IN NORMAL RENAL FUNCTION<\/h3>\n<\/li>\n
  • Simplex treatment: 200\u2013400 mg 5 times daily<\/li>\n
  • Prophylaxis (immunocompromised): 200\u2013400 mg every 6 hours<\/li>\n
  • Suppression: 200 mg every 6 hours, or 400 mg every 12 hours<\/li>\n
  • Zoster: 800 mg 5 times a day for 7 days
    \n

    PHARMACOKINETICS<\/h3>\n<\/li>\n
  • Molecular weight                           :225.2<\/li>\n
  • %Protein binding                           :9\u201333<\/li>\n
  • %Excreted unchanged in urine     : 40\u201370<\/li>\n
  • Volume of distribution (L\/kg)       :0.7<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :2.9\/19.5 (dialysis: 5.7)
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n

    25\u201350 Dose as in normal renal function 10\u201325 Simplex: 200 mg 3\u20134 times daily. Zoster: 800 mg every 8\u201312 hours<\/li>\n

  • <10           : Simplex: 200 mg every 12 hours. Zoster: 400\u2013800 mg every 12 hours
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Not dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • HD                     :Dialysed. Dose as in GFR<\/li>\n
  • <10           : mL\/min. Give dose after dialysis<\/li>\n
  • HDF\/high flux   :Dialysed. Dose as in GFR<\/li>\n
  • <10           : mL\/min. Give dose after dialysis<\/li>\n
  • CAV\/VVHD      :Dialysed. Dose as in GFR=10\u201320 mL\/min
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Ciclosporin: reports of increase and decrease in ciclosporin levels; some editors report no experience of interaction locally; possibly increased risk of nephrotoxicity.<\/li>\n
  • Higher plasma levels of aciclovir and mycophenolate mofetil with concomitant administration<\/li>\n
  • Tacrolimus: possibly increased risk of nephrotoxicity
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    Dispersible tablets may be dispersed in a minimum of 50 mL of water or swallowed whole with a little water<\/p>\n

    OTHER INFORMATION<\/h4>\n<\/li>\n
  • Consider IV therapy for herpes zoster infection if patient severely immunocompromised<\/li>\n
  • Plasma aciclovir concentration is reduced by 60% during haemodialysis<\/li>\n","protected":false},"excerpt":{"rendered":"

    Aciclovir oral CLINICAL USE Antiviral agent: Herpes simplex and herpes<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1608","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1608","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1608"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1608\/revisions"}],"predecessor-version":[{"id":2915,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1608\/revisions\/2915"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1608"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1608"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1608"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}