{"id":1601,"date":"2023-06-25T17:27:16","date_gmt":"2023-06-25T17:27:16","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/acarbose\/"},"modified":"2023-06-25T19:57:49","modified_gmt":"2023-06-25T19:57:49","slug":"acarbose","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/acarbose\/","title":{"rendered":"Acarbose"},"content":{"rendered":"

<\/p>\n

Acarbose<\/h1>\n

CLINICAL USE<\/h3>\n

Antidiabetic agent<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

50\u2013200 mg 3 times a day<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           :
    \n645.6<\/li>\n
  • %Protein binding                           :
    \n15<\/li>\n
  • %Excreted unchanged in urine     :
    \n1.7 (35% including
    \ninactive metabolites)<\/li>\n
  • Volume of distribution (L\/kg)       :
    \n0.32<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :
    \n3\u20139\/Increased<\/p>\n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n

    25\u201350 Dose as in normal renal function
    \n10\u201325 Avoid<\/li>\n

  • <10           :
    \nAvoid<\/p>\n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :
    \nUnknown dialysability. Avoid<\/li>\n
  • HD                             :
    \nUnknown dialysability. Avoid. See
    \n\u2018Other Information\u2019<\/li>\n
  • HDF\/high flux   :
    \nUnknown dialysability. Avoid. See
    \n\u2018Other Information\u2019<\/li>\n
  • CAV\/VVHD      :
    \nUnknown dialysability. Avoid<\/p>\n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugs<\/li>\n

  • Antibacterials: hypoglycaemic effectpossibly enhanced and increased
    \ngastrointestinal side effects with neomycin<\/li>\n
  • Lipid lowering agents: hypoglycaemiceffect possibly enhanced by colestyramine
    \n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    OTHER INFORMATION<\/h4>\n<\/li>\n
  • Only 1\u20132% of active drug is absorbed<\/li>\n
  • In renal impairment, peak concentrationsare 5 times higher than in the general
    \npopulation and the AUC is 6 times higher<\/li>\n
  • One paper records the use of acarbosein a haemodialysis patient who had
    \nundergone a total gastrectomy to treat
    \noxyhyperglycaemia: using a dose of
    \n100 mg before meals.<\/p>\n

    with food<\/li>\n","protected":false},"excerpt":{"rendered":"

    Acarbose CLINICAL USE Antidiabetic agent DOSE IN NORMAL RENAL FUNCTION<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1601","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1601","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1601"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1601\/revisions"}],"predecessor-version":[{"id":2918,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1601\/revisions\/2918"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1601"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1601"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1601"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}