{"id":1600,"date":"2023-06-25T17:27:16","date_gmt":"2023-06-25T17:27:16","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/acamprosate-calcium\/"},"modified":"2023-06-25T19:57:45","modified_gmt":"2023-06-25T19:57:45","slug":"acamprosate-calcium","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/acamprosate-calcium\/","title":{"rendered":"ACAMPROSATE CALCIUM"},"content":{"rendered":"

<\/p>\n

ACAMPROSATE CALCIUM<\/h1>\n

CLINICAL USE<\/h3>\n

Maintenance of abstinence in alcohol dependence<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n
  • <60 kg: 666 mg 3 times a day<\/li>\n
  • >60 kg: 666 mg at breakfast, 333 mg at midday and 333 mg at night
    \n

    PHARMACOKINETICS<\/h3>\n<\/li>\n
  • Molecular weight                           :400.5<\/li>\n
  • %Protein binding                           :0<\/li>\n
  • %Excreted unchanged in urine     : Majority<\/li>\n
  • Volume of distribution (L\/kg)       :Approximately 1<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :33\/85.8
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n

    30\u201350 333 mg 3 times daily10\u201330 333 mg twice daily<\/li>\n

  • <10           : 333 mg once daily
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                :Dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • HD                     :Dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • HDF\/high flux   :Dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • CAV\/VVHD      :Dialysed. Dose as in GFR=10\u201330 mL\/min
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugsNone known<\/p>\n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    \u2013<\/p>\n

    Route<\/h4>\n

    Oral<\/p>\n

    Rate of Administration<\/h4>\n

    \u2013<\/p>\n

    Comments<\/h4>\n

    \u2013<\/p>\n

    OTHER INFORMATION<\/h4>\n<\/li>\n
  • Recommended treatment period is a year<\/li>\n
  • After a single dose of 666 mg in patients with severe renal impairment, the average maximum concentration was 4 times that in healthy individuals<\/li>\n
  • Bioavailability is reduced if administered with food<\/li>\n","protected":false},"excerpt":{"rendered":"

    ACAMPROSATE CALCIUM CLINICAL USE Maintenance of abstinence in alcohol dependence<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1600","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1600","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1600"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1600\/revisions"}],"predecessor-version":[{"id":2917,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1600\/revisions\/2917"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1600"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1600"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1600"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}