{"id":1594,"date":"2023-06-24T21:34:38","date_gmt":"2023-06-24T21:34:38","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/abatacept\/"},"modified":"2023-06-25T19:55:21","modified_gmt":"2023-06-25T19:55:21","slug":"abatacept","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/abatacept\/","title":{"rendered":"Abatacept"},"content":{"rendered":"

<\/p>\n

CLINICAL USE<\/h3>\n

Treatment of moderate to severe rheumatoid arthritis in people who have not responded adequately to other treatment<\/p>\n

DOSE IN NORMAL RENAL FUNCTION<\/h3>\n

<60 kg: 500 mg, 60\u2013100 kg: 750 mg, >100 kg: 1000 mgevery 4 weeks after loading<\/p>\n

PHARMACOKINETICS<\/h3>\n
  • Molecular weight                           :92 000<\/li>\n
  • %Protein binding                           :No data<\/li>\n
  • %Excreted unchanged in urine     : No data<\/li>\n
  • Volume of distribution (L\/kg)       :0.07<\/li>\n
  • half-life \u2013 normal\/ESRD (hrs)      :13.1 days\/\u2013
    \n

    DOSE IN RENAL IMPAIRMENT<\/h3>\n

    GFR (mL\/MIN)<\/h4>\n<\/li>\n
  • 20 to 50     : Dose as in normal renal function<\/li>\n
  • 10 to 20     : Dose as in normal renal function. Use with caution<\/li>\n
  • <10           : Dose as in normal renal function. Use with caution
    \n

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES<\/h3>\n<\/li>\n
  • CAPD                        : Unlikely to be dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • HD                             :Unlikely to be dialysed. Dose as in GFR<<10 mL\/min<\/li>\n
  • HDF\/high flux           :Unlikely to be dialysed. Dose as in GFR <10 mL\/min<\/li>\n
  • CAV\/VVHD               :Unlikely to be dialysed. Dose as in GFR10 to 20 mL\/min
    \n

    IMPORTANT DRUG INTERACTIONS<\/h3>\n

    Potentially hazardous interactions with other drugsVaccines: avoid concomitant use with live vaccines<\/p>\n

    ADMINISTRATION<\/h3>\n

    Reconstition<\/h4>\n

    With 10 mL of water for injection per vial<\/p>\n

    Route<\/h4>\n

    IV infusion<\/h4>\n

    Rate of Administration<\/h4>\n

    Over 30 minutes<\/p>\n

    Comments<\/h4>\n

    DO NOT SHAKE when reconstituting Add dose to 100 mL of sodium chloride 0.9%<\/p>\n

    OTHER INFORMATION<\/h4>\n

    Stable for 24 hours at 2\u20138\u00b0C if made under aseptic conditionsAdminister with an infusion set with a low protein binding filter (pore size 0.2\u20131.2 \u03bcm)Manufacturer does not have any information on its use in renal impairment. Main side effects are infections and malignancies, to which renal patients may be at increased risk, therefore use with caution<\/li>\n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Treatment of moderate to severe rheumatoid arthritis in<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-1594","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1594","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=1594"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1594\/revisions"}],"predecessor-version":[{"id":1596,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/1594\/revisions\/1596"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=1594"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=1594"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=1594"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}