Analgesics: increased risk of bleeding with IV diclofenac and ketorolac – avoid concomitant use Antidiabetic agents: enhanced hypoglycaemic effect with sulphonylureas Camomile: enhanced anticoagulation
Ciclosporin: there have been a few reports of altered anticoagulant effect; decreased ciclosporin levels have been seen rarely Cytotoxics: increased risk of bleeding with erlotinib and imatinib; enhanced effect with etoposide, fluorouracil, ifosfamide and sorafenib Melatonin: possibly enhanced INR
ADMINISTRATION
Reconstition
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Route
Oral
Rate of Administration
–
Comments
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OTHER INFORMATION
Inactive metabolites renally excreted and may accumulate in renal impairment Reduced protein binding in renal impairment .