CLINICAL USE

Vitamin B and C supplementation

DOSE IN NORMAL RENAL FUNCTION

Vitamin B Compound Strong: 1–2 tablets 1 to 3 times daily Pabrinex: Ampoules No 1 and No 2 every 8–12 hours depending on indication Can be given post dialysis for vitamin supplementation

PHARMACOKINETICS

  • Molecular weight                           : N/A
  • %Protein binding                           : N/A
  • %Excreted unchanged in urine     : N/A
  • Volume of distribution (L/kg)       : N/A
  • half-life – normal/ESRD (hrs)      : N/A

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function
  • 10 to 20     : Dose as in normal renal function
  • <10           : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                : Dialysed. Dose as in normal renal function
  • HD                     : Dialysed. Dose as in normal renal function
  • HDF/high flux   : Dialysed. Dose as in normal renal function
  • CAV/VVHD      : Dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugs

  • None known

    ADMINISTRATION

    Reconstition

    –

    Route

    Oral, IV, IM

    Rate of Administration

    Bolus: Max volume of 10 mL over 10 minutes Infusion: 15–30 minutes

    Comments

    Dilute in 50–100 mL sodium chloride or glucose 5%

    OTHER INFORMATION

    NOT PRESCRIBABLE ON FP10 PRESCRIPTION Supplement in

  • HD                     : patients due to loss on dialysis and poor diet Available as Nephrovite ® (Kimal) and Dialyvit® (Vitaline) – each tablet contains: Vitamin B1 (thiamine) 1.5 mg Vitamin B2 (riboflavin) 1.7 mg Vitamin B3 (niacinamide) 20 mg Vitamin B6 (pyridoxine) 10 mg Vitamin B12 (cyanocobalamin) 6 mcg Vitamin C 60 mg Biotin 300 mcg Pantothenic acid 10 mg Folic acid 800 mcg Ketovite ®, each tablet contains: Vitamin B1 (thiamine) 1 mg Vitamin B2 (riboflavin) 1 mg Acetomenaphthone 500 mcg Vitamin B6 (pyridoxine) 330 mcg Nicotinamide 3.3 mg Vitamin C 16.6 mg Biotin 170 mcg Pantothenic acid 1.16 mg Alpha tocopheryl acetate 5 mg Inositol 50 mg Folic acid 250 mcg Pabrinex: Vitamin B1 (thiamine) 250 mg Vitamin B2 (riboflavin) 4 mg Vitamin B6 (pyridoxine) 50 mg Vitamin C 500 mg Nicotinamide 160 mg Vitamin B and C preparations .
    • Tags:

    Related News

    ffddfd

    Hyperlipidemia