Vigabatrin.txt CLINICAL USE Anti-epileptic agent DOSE IN NORMAL RENAL FUNCTION 1–3 g daily in single or divided doses PHARMACOKINETICS Molecular weight                           : 129.2 %Protein binding                           : Negligible %Excreted unchanged in urine     : 60–80 Volume of distribution (L/kg)       : 0.8 half-life – normal/ESRD (hrs)      : 5–8/13–15 DOSE IN RENAL IMPAIRMENT GFR (mL/MIN) 20 to 50     : Give 50% of normal dose and titrate to response 10 to 20     : Give 50% of normal dose and titrate to response <10           : Give 25% of normal dose and titrate to response DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES CAPD                : Unknown dialysability. Dose as for GFR <10 mL/min HD                     : Dialysed. Dose as for GFR <10 mL/min HDF/high flux   : Dialysed. Dose as for GFR <10 mL/min CAV/VVHD      : Unknown dialysability. Dose as for GFR 10 to 20 mL/min IMPORTANT DRUG INTERACTIONS Potentially hazardous interactions with other drugs Antidepressants: anticonvulsant effect antagonised, convulsive threshold lowered Anti-epileptics: concentration of phenytoin and possibly phenobarbital and primidone reduced Antimalarials: mefloquine antagonises anticonvulsant effect; chloroquine and hydroxychloroquine occasionally reduce convulsive threshold ADMINISTRATION Reconstition – Route Oral Rate of Administration – Comments – . Tags: post-by-auto-php Continue Reading Previous Previous post: VOLVULUS.txtNext Next post: Zuclopenthixol.txt Related News sotalol hydrochloride.txt tazocin.txt