Potentially hazardous interactions with other drugs ACE inhibitors and angiotensin-II antagonists: enhanced hypotensive effect (risk of severe hyperkalaemia)
Analgesics: increased risk of nephrotoxicity with NSAIDs; increased risk of hyperkalaemia, especially with indometacin; antagonism of hypotensive effect
Antibacterials: avoid concomitant use with lymecycline
Antidepressants: enhanced hypotensive effect with MAOIs; increased risk of postural hypotension with tricyclics
Antipsychotics: enhanced hypotensive effect with phenothiazines Antihypertensives: enhanced hypotensive effect; increased risk of first dose hypotensive effect of post-synaptic alpha- blockers, e.g. prazosin
Ciclosporin: increased risk of hyperkalaemia
Lithium: reduced excretion of lithium (risk of lithium toxicity)
Potassium salts: increased risk of hyperkalaemia
Tacrolimus: increased risk of hyperkalaemia
ADMINISTRATION
Reconstition
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Route
Oral
Rate of Administration
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Comments
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OTHER INFORMATION
Hyperkalaemia is common when GFR<30 mL/min. May cause acute renal failure Potassium-sparing diuretics are weak diuretics and are ineffective in moderate to severe renal failure .