20 to 50     : Dose as in normal renal function
10 to 20     : Dose as in normal renal function. Use with caution
<10           : Dose as in normal renal function. Use with caution
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                : Unlikely to be dialysed. Dose as in GFR <10 mL/min
HD                     : Unlikely to be dialysed. Dose as in GFR <10 mL/min
HDF/high flux   : Unlikely to be dialysed. Dose as in GFR <10 mL/min
CAV/VVHD      : Unknown dialysability. Dose as in GFR 10 to 20 mL/min
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
None known
ADMINISTRATION
Reconstition
7.2 mL water for injection per 150 mg vial
Route
IV infusion
Rate of Administration
4 mg/kg over 90 minutes 2 mg/kg over 30 minutes
Comments
Allow to stand for 5 minutes after reconstitution Dilute dose in 250 mL sodium chloride 0.9%
OTHER INFORMATION
Distributes to normal cells, tumour cells and serum where HER2 antigens are found Remains in body for 24 weeks Doesn’t require hepatic or renal metabolism for elimination Nadir for bone-marrow depression is 4 weeks with recovery within 6 weeks Associated with cardiotoxicity May remain in circulation for up to 24 weeks .