CLINICAL USE

Haemostatic agent

DOSE IN NORMAL RENAL FUNCTION

Oral: 1–1.5 g every 8–12 hours (15–25 mg/ kg every 8–12 hours) IV: 0.5–1 g every 8 hours (25–50 mg/kg daily in divided doses) Dose depends on indication

PHARMACOKINETICS

  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 157.2
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 3
  • %Excreted unchanged in urine &nbsp &nbsp : 90
  • Volume of distribution (L/kg) &nbsp &nbsp &nbsp : 1
  • half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp : 2/–

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50 &nbsp &nbsp : IV: 10 mg/kg 12 hourly. Oral: 25 mg/ kg 12 hourly
  • 10 to 20 &nbsp &nbsp : IV: 10 mg/kg 12–24 hourly. Oral: 25 mg/kg 12–24 hourly
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : IV: 5 mg/kg 12–24 hourly. Oral: 12.5 mg/kg 12–24 hourly

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp: Unknown dialysability. Dose as in GFR <10 mL/min

  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : Unknown dialysability. Dose as in GFR <10 mL/min
  • HDF/high flux &nbsp : Unknown dialysability. Dose as in GFR <10 mL/min
  • CAV/VVHD &nbsp &nbsp &nbsp: Unknown dialysability. Dose as in GFR 10 to 20 mL/min

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugs
  • None known

    ADMINISTRATION

    Reconstition

    Route

    IV, oral

    Rate of Administration

    Slow bolus =100 mg/minute or continuous

    IV infusion

    in glucose 5% or sodium chloride 0.9%

    Comments

    OTHER INFORMATION

    A 5% topical solution can be made up using the IV preparation, mixed with water for injection. This can be used as a mouthwash to stop bleeding after dental surgery, or placed on a swab to reduce bleeding at fistula or other bleeding sites if conventional measures have not worked (anecdotal) .