Oral: 1–1.5 g every 8–12 hours (15–25 mg/ kg every 8–12 hours) IV: 0.5–1 g every 8 hours (25–50 mg/kg daily in divided doses) Dose depends on indication
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                : Unknown dialysability. Dose as in GFR <10 mL/min
HD                     : Unknown dialysability. Dose as in GFR <10 mL/min
HDF/high flux   : Unknown dialysability. Dose as in GFR <10 mL/min
CAV/VVHD      : Unknown dialysability. Dose as in GFR 10 to 20 mL/min
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
None known
ADMINISTRATION
Reconstition
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Route
IV, oral
Rate of Administration
Slow bolus =100 mg/minute or continuous
IV infusion
in glucose 5% or sodium chloride 0.9%
Comments
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OTHER INFORMATION
A 5% topical solution can be made up using the IV preparation, mixed with water for injection. This can be used as a mouthwash to stop bleeding after dental surgery, or placed on a swab to reduce bleeding at fistula or other bleeding sites if conventional measures have not worked (anecdotal) .