20 to 50     : Dose as in normal renal function
10 to 20     : Dose as in normal renal function
<10           : Dose as in normal renal function
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                : Not dialysed. Dose as for GFR <10 mL/min
HD                     : Not dialysed. Dose as for GFR <10 mL/min
HDF/high flux   : Unknown dialysability. Dose as for GFR <10 mL/min
CAV/VVHD      : Not dialysed. Dose as for GFR 10 to 20 mL/min
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs Antacids: avoid giving for 2 hours after tipranavir administration
Antibacterials: plasma concentration of clarithromycin and other macrolides increased – reduce dose of clarithromycin in renal impairment; concentration increased by clarithromycin; rifabutin concentration increased (risk of uveitis) – reduce dose; concentration reduced by rifampicin – avoid concomitant use; avoid concomitant use with telithromycin in severe renal and hepatic failure
Antidepressants: concentration possibly reduced by St John’s wort – avoid concomitant use
Antimalarials: possibly increased risk of ventricular arrhythmias with artemether/ lumefantrine – avoid concomitant use
Antivirals: reduces concentration of abacavir, amprenavir, didanosine, lopinavir, saquinavir and zidovudine; concentration increased by atazanavir
Ciclosporin: levels possibly altered by tipranavir Sirolimus: levels possibly altered by tipranavir
Tacrolimus: levels possibly altered by tipranavir
ADMINISTRATION
Reconstition
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Route
Oral
Rate of Administration
–
Comments
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OTHER INFORMATION
Administer with food; enhanced bioavailability with high fat meals .