Tiotropium.txt

CLINICAL USE

Maintenance treatment of chronic obstructive pulmonary disease

DOSE IN NORMAL RENAL FUNCTION

18 micrograms once daily

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 472.4 (as bromide)

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 72

%Excreted unchanged in urine &nbsp &nbsp : 14 (of inhaled dose)

Volume of distribution (L/kg) &nbsp &nbsp &nbsp : 32

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp : 5–6 days/Increased

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function

10 to 20 &nbsp &nbsp : Dose as in normal renal function. Use with caution

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function. Use with caution

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp: Unknown dialysability. Dose as in normal renal function. Use with caution

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : Unknown dialysability. Dose as in normal renal function. Use with caution

HDF/high flux &nbsp : Unknown dialysability. Dose as in normal renal function. Use with caution

CAV/VVHD &nbsp &nbsp &nbsp: Unknown dialysability. Dose as in normal renal function. Use with caution

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs Avoid administration with other anti- cholinergic drugs

ADMINISTRATION

Reconstition

–

Route

Inhalation

Rate of Administration

–

Comments

–

OTHER INFORMATION

Not to be used for acute episodes of bronchospasm .

Tags: post-by-auto-php