Tinidazole.txt

CLINICAL USE

Antibacterial agent

DOSE IN NORMAL RENAL FUNCTION

1–2 g daily

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 247.3

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 8–121

%Excreted unchanged in urine &nbsp &nbsp : 20–25

Volume of distribution (L/kg) &nbsp &nbsp &nbsp : 0.61–0.671

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp : 12–14/Unchanged

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function

10 to 20 &nbsp &nbsp : Dose as in normal renal function

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp: Unknown dialysability, but likely to be dialysed. Dose as in normal renal function

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : Dialysed. Dose as in normal renal function

HDF/high flux &nbsp : Dialysed. Dose as in normal renal function

CAV/VVHD &nbsp &nbsp &nbsp: Unknown dialysability. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Alcohol: disulfiram-like reaction

ADMINISTRATION

Reconstition

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Route

Oral

Rate of Administration

–

Comments

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OTHER INFORMATION

Dosage adjustment in renal failure is not necessary as a decrease in renal clearance is compensated for by increased faecal excretion of tinidazole 43% can be removed during a 6 hour haemodialysis session. .

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