Timentin.txt

DOSE IN NORMAL RENAL FUNCTION

3.2 g every 6–8 hours, increased to every 4 hours in severe infections

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : Ticarcillin (as Na) 428.4, clavulanic acid 199.2

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : Ticarcillin 50, clavulanic acid 25

%Excreted unchanged in urine &nbsp &nbsp : Ticarcillin 85–90, clavulanic acid 40

Volume of distribution (L/kg) &nbsp &nbsp &nbsp : Ticarcillin 0.14–0.21, clavulanic acid 0.3

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp : Ticarcillin 1.2/15, clavulanic acid 1/3–4

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

>30 3.2 g every 8 hours 10–30 1.6 g every 8 hours

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : 1.6 g every 12 hours

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp: Not dialysed. Dose as in GFR <10 mL/min

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : Dialysed. Dose as in GFR <10 mL/min

HDF/high flux &nbsp : Dialysed. Dose as in GFR <10 mL/min

CAV/VVHD &nbsp &nbsp &nbsp: Unknown dialysability. Dose as in GFR=10–30 mL/min or 2.4 g every 6–8 hours1 CVVhd/ HDF Dialysed. 3.2 g every 6 hours1

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Anticoagulants: effects of coumarins are potentially enhanced Oral contraceptives: potentially reduced efficacy Methotrexate: reduced excretion thereby increasing risk of toxicity

ADMINISTRATION

Reconstition

With 10 mL water for injection and add to 100 mL glucose 5%

Route

Rate of Administration

30–40 minutes

Comments

Each 3.2 g of ticarcillin/clavulanic acid contains 16 mmol of sodium and 1 mmol of potassium

OTHER INFORMATION

CSM has advised that cholestatic jaundice may occur if treatment exceeds a period of 14 days and can present up to 6 weeks after treatment has been stopped. The incidence of cholestatic jaundice occurring with Timentin is higher in males than in females and is particularly prevalent in men over the age of 65 years

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