CAV/VVHD      : Unlikely to be dialysed. Avoid
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs Calcium salts: reduced absorption
ADMINISTRATION
Reconstition
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Route
Oral
Rate of Administration
–
Comments
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OTHER INFORMATION
Take as a single dose with a glass of water at least 2 hours before or after meals, calcium supplements or aluminium or magnesium containing antacids Patients should ensure their calcium and vitamin D intake is adequate Calcium metabolism disorders should be corrected before starting therapy Bisphosphonates are mainly eliminated by excretion of unchanged drug in the urine .