CLINICAL USE
Paget’s disease of bone
DOSE IN NORMAL RENAL FUNCTION
400 mg daily for 12 weeks
PHARMACOKINETICS
DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
60–90 Use with caution 30–60 Use with caution <30 Avoid
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs Calcium salts: reduced absorption
ADMINISTRATION
Reconstition
–
Route
Oral
Rate of Administration
–
Comments
–
OTHER INFORMATION
Take as a single dose with a glass of water at least 2 hours before or after meals, calcium supplements or aluminium or magnesium containing antacids Patients should ensure their calcium and vitamin D intake is adequate Calcium metabolism disorders should be corrected before starting therapy Bisphosphonates are mainly eliminated by excretion of unchanged drug in the urine .
