Tigecycline.txt

CLINICAL USE

Antibacterial agent

DOSE IN NORMAL RENAL FUNCTION

Loading dose of 100 mg, then 50 mg twice daily

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 585.6

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 71–89

%Excreted unchanged in urine &nbsp &nbsp : 22

Volume of distribution (L/kg) &nbsp &nbsp &nbsp : 7–9

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp : 42/Probably unchanged

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function

10 to 20 &nbsp &nbsp : Dose as in normal renal function

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp: Not dialysed. Dose as in normal renal function

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : Not dialysed. Dose as in normal renal function

HDF/high flux &nbsp : Unknown dialysability. Dose as in normal renal function

CAV/VVHD &nbsp &nbsp &nbsp: Unknown dialysability. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Anticoagulants: possibly enhanced anticoagulant effect of coumarins

Oestrogens: possibly reduced contraceptive effects of oestrogens (risk probably small)

ADMINISTRATION

Reconstition

5.3 mL of sodium chloride 0.9% or glucose 5% (gently swirl to reconstitute)

Route

IV infusion

Rate of Administration

30–60 minutes

Comments

Add required dose to 100 mL of sodium chloride 0.9% or glucose 5%

OTHER INFORMATION

AUC increased by 30% in CKD 5 .

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