Temocillin

CLINICAL USE

Antibacterial agent

DOSE IN NORMAL RENAL FUNCTION

1–2 g every 12 hoursAcute uncomplicated UTIs: 1 g daily in a single or divided doses

PHARMACOKINETICS

Molecular weight :458.4 (as sodium salt)

%Protein binding :75–85

%Excreted unchanged in urine : 90

Volume of distribution (L/kg) :0.23

half-life – normal/ESRD (hrs) :3.1–5.4/28.2

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

30–50 Dose as in normal renal function 10–30 1–2 g daily

<10 : 1–2 g every 48 hours

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Not dialysed. Dose as in GFR <10 mL/min

HD :Dialysed. Dose as in GFR <10 mL/min

HDF/high flux :Dialysed. Dose as in GFR <10 mL/min

CAV/VVHD :Dialysed. Dose as in GFR=10–30 mL/min

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugsTemocillin can reduce the excretion of methotrexate (increased risk of toxicity)

ADMINISTRATION

Reconstition

IV: Dissolve in 20 mL water for injection

IV infusion

: Dilute in 50–100 mL sodium chloride 0.9%IM: Dissolve in 2 mL water for injection or lidocaine 0.5–1% (volume 2.7 mL)

Route

IV, IM

Rate of Administration

Slow IV bolus over 3–4 minutes Infusion over 30–40 minutes

Comments

Incompatible with proteins, blood products, lipid emulsions and aminoglycosides

OTHER INFORMATION

Bleeding has occurred in some patients (more likely in those with renal impairment)20% is removed by haemodialysis and 17–26% by peritoneal dialysis.

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