20 to 50     : Dose as in normal renal function
10 to 20     : Dose as in normal renal function. Start with small doses
<10           : Dose as in normal renal function. Start with small doses
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Unlikely to be dialysed. Dose as in GFR <10 mL/min
HD                     :Not dialysed. Dose as in GFR <10 mL/min
HDF/high flux   :Unknown dialysability. Dose as in GFR <10 mL/min
CAV/VVHD      :Not dialysed. Dose as in GFR 10 to 20 mL/min
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
Antibacterials: metabolism possibly increased by rifampicin
Antipsychotics: increased sedative effects
Antivirals: concentration possibly increased by ritonavirDisulfiram: metabolism of temazepam inhibited (increased toxicity)Sodium oxybate: enhanced effects of sodium oxybate – avoid
ADMINISTRATION
Reconstition
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Route
Oral
Rate of Administration
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Comments
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OTHER INFORMATION
Increased CNS sensitivity in renal impairmentLong-term use may lead to dependence and withdrawal symptoms in certain patients80% of metabolites excreted in the urine