Temazepam – kdc

CLINICAL USE

Benzodiazepine:Insomnia (short-term use) Pre-med anxiolytic prior to minor procedures

DOSE IN NORMAL RENAL FUNCTION

10–40 mg at night Premedication: 20–40 mg, 60 minutes prior to procedure

PHARMACOKINETICS

Molecular weight :300.7

%Protein binding :96

%Excreted unchanged in urine : <2

Volume of distribution (L/kg) :1.3–1.5

half-life – normal/ESRD (hrs) :7–11/Unchanged

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function. Start with small doses

<10 : Dose as in normal renal function. Start with small doses

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Unlikely to be dialysed. Dose as in GFR <10 mL/min

HD :Not dialysed. Dose as in GFR <10 mL/min

HDF/high flux :Unknown dialysability. Dose as in GFR <10 mL/min

CAV/VVHD :Not dialysed. Dose as in GFR 10 to 20 mL/min

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Antibacterials: metabolism possibly increased by rifampicin

Antipsychotics: increased sedative effects

Antivirals: concentration possibly increased by ritonavirDisulfiram: metabolism of temazepam inhibited (increased toxicity)Sodium oxybate: enhanced effects of sodium oxybate – avoid

ADMINISTRATION

Reconstition

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Route

Oral

Rate of Administration

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Comments

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OTHER INFORMATION

Increased CNS sensitivity in renal impairmentLong-term use may lead to dependence and withdrawal symptoms in certain patients80% of metabolites excreted in the urine

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