20 to 50     : Dose as in normal renal function
10 to 20     : Dose as in normal renal function, use with caution
<10           : Dose as in normal renal function, use with caution
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Unknown dialysability. Dose as in GFR <10 mL/min
HD                     :Unknown dialysability. Dose as in GFR <10 mL/min
HDF/high flux   :Unknown dialysability. Dose as in GFR <10 mL/min
CAV/VVHD      :Unknown dialysability. Dose as in normal renal function. Use with caution
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
Antidepressants: risk of CNS toxicity with MAOIs, moclobemide, SSRIs, sertraline, St John’s wort – avoid concomitant use; possibly increased serotonergic effects with duloxetine
Ergot alkaloids: increased risk of vasospasm – avoid concomitant use
ADMINISTRATION
Reconstition
Injection is pre-filled into syringes ready for administration
Route
Oral, SC, nasal spray
Rate of Administration
–
Comments
–
OTHER INFORMATION
Non-renal clearance accounts for about 80% of the total clearance. The remaining 20% is excreted in urine, mainly as metabolites, by active renal tubular secretion.
