CLINICAL USE
Treatment and prophylaxis of sodium chloride deficiency
DOSE IN NORMAL RENAL FUNCTION
Oral prophylaxis: 40–80 mmol sodium daily, up to a maximum of 200 mmol sodium dailyIV: in severe deficiency 2–3 litres over 2–3 hours then reduce
PHARMACOKINETICS
DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsMay impair the efficacy of antihypertensive drugs in chronic renal failure
ADMINISTRATION
Reconstition
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Route
Oral, IV
Rate of Administration
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Comments
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OTHER INFORMATION
Other regimens: for acute muscular cramps post haemodialysis, 10 mL sodium chloride 30% injection diluted in 100 mL sodium chloride 0.9%, and infused over 30 minutes or in dialysis washbackSodium salts should be administered with caution to patients with congestive heart failure, peripheral or pulmonary oedema, or impaired renal functionSlow sodium ® 600 mg tablet approximately 10 mmol sodium and 10 mmol chloride.